Photeroids A and B, unique phenol-sesquiterpene meroterpenoids from the deep-sea-derived fungus Phomopsis tersa

被引：24

作者：

Chen, Shanchong ^{[1
,2
]}

Liu, Zhaoming ^{[1
]}

Tan, Haibo ^{[3
]}

Chen, Yuchan ^{[1
]}

Zhu, Shuang ^{[2
]}

Liu, Hongxin ^{[1
]}

Zhang, Weimin ^{[1
]}

机构：

[1] Guangdong Acad Sci, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangdong Open Lab Appl Microbiol,Guangdong Inst, Guangzhou 510070, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Guangzhou 510006, Peoples R China

[3] Chinese Acad Sci, Program Nat Prod Chem Biol, Key Lab Plant Resources Conservat & Sustainable U, Guangdong Prov Key Lab Appl Bot,South China Bot G, Guangzhou 510650, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

MARINE NATURAL-PRODUCTS;

D O I：

10.1039/c9ob02625h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Photeroids A (1) and B (2), two structurally fascinating meroterpenoids, were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Their structures were sufficiently established by a comprehensive interpretation of the spectroscopic data, NMR spectra, and ECD calculation. Photeroids A and B represented the first phenolic sesquiterpene meroterpenoids featuring a highly fused 6/6/6/6 tetracyclic ring system derived through a rarely-occurring hetero-Diels-Alder reaction via an orthoquinone methide intermediate. Additionally, they were also evaluated for their cytotoxic activities against four human cancer cells, wherein compounds 1 and 2 exhibited moderate cytotoxic activities.

引用

页码：642 / 645

页数：4

共 15 条

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