The ciliary membrane

被引：123

作者：

Rohatgi, Rajat ^{[1
]}

Snell, William J. ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 04期

关键词：

PRIMARY CILIUM; BASAL BODY; CELL BODY; PROTEIN; CILIOGENESIS; CENTRIOLES; TRANSPORT; TRANSDUCTION; TRAFFICKING; FLAGELLA;

D O I：

10.1016/j.ceb.2010.03.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.

引用

页码：541 / 546

页数：6

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