N-terminal POMC peptides and adrenal growth

被引：11

作者：

Bicknell, Andrew B. ^{[1
]}

机构：

[1] Univ Reading, Sch Biol Sci, Reading, Berks, England

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2016年 / 56卷 / 04期

关键词：

N-POMC; adrenal; pro-gamma-MSH; growth; POMC; HPA axis; PRO-OPIOMELANOCORTIN PEPTIDES; GAMMA-MELANOTROPIN PRECURSOR; HUMAN PITUITARY-GLANDS; TRYPSIN-LIKE PROTEASE; ADRENOCORTICOTROPIC HORMONE; BETA-CORTICOTROPIN; COMMON PRECURSOR; PROOPIOMELANOCORTIN DEFICIENCY; ADRENOTROPIC HORMONE; OPIOCORTIN PEPTIDES;

D O I：

10.1530/JME-15-0269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The peptide hormones contained within the sequence of proopiomelanocortin (POMC) have diverse roles ranging from pigmentation to regulation of adrenal function to control of our appetite. It is generally acknowledged to be the archetypal hormone precursor, and as its biology has been unravelled, so too have many of the basic principles of hormone biosynthesis and processing. This short review focuses on one group of its peptide products, namely, those derived from the N-terminal of POMC and their role in the regulation of adrenal growth. From a historical and a personal perspective, it describes how their role in regulating proliferation of the adrenal cortex was identified and also highlights the key questions that remain to be answered.

引用

页码：T39 / T48

页数：10

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