Gastric cancer: Who is at risk?

被引：18

作者：

Zagari, RM ^{[1
]}

Bazzoli, F ^{[1
]}

机构：

[1] Univ Bologna, Policlin S Orsola, Dept Internal Med & Gastroenterol, IT-40138 Bologna, Italy

来源：

DIGESTIVE DISEASES | 2004年 / 22卷 / 04期

关键词：

gastric cancer; dietary factors; host genetic factors; Helicobacter pylori;

D O I：

10.1159/000083590

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastric cancer is a multifactorial disease. Helicobacter pylori infection, host genetic factors and dietetic factors play an important role in the development of gastric cancer. Individuals with a positive family history of gastric cancer and/or pro-inflammatory polymorphisms of the interleukin-1 and tumor necrosis factor A genes infected by H. pylori virulent strains ( cagA-, vacA s1-, vacA m1- and babA2-positive) have the highest risk of gastric cancer development. Diets rich in salted and smoked food and poor in fresh fruit and vegetables favor gastric carcinogenesis. Genetic combined with bacterial and host genotyping may allow for the identification of patients at high risk of gastric cancer who can benefit from preventive eradication therapy. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：302 / 305

页数：4

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