Cholinergic enhancement and increased selectivity of perceptual processing during working memory

被引：243
作者：
Furey, ML [1 ]
Pietrini, P
Haxby, JV
机构：
[1] NIMH, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA
[2] Univ Pisa, Dept Human & Environm Sci, Pisa, Italy
来源：
SCIENCE | 2000年 / 290卷 / 5500期
关键词：
D O I：
10.1126/science.290.5500.2315
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Using functional magnetic resonance imaging, we investigated the mechanism by which cholinergic enhancement improves working memory. We studied the effect of the cholinesterase inhibitor physostigmine on subcomponents of this complex function. Cholinergic enhancement increased the selectivity of neural responses in extrastriate cortices during visual working memory, particularly during encoding, It also increased the participation of ventral extrastriate cortex during memory maintenance and decreased the participation of anterior prefrontal cortex. These results indicate that cholinergic enhancement improves memory performance by augmenting the selectivity of perceptual processing during encoding, thereby simplifying processing demands during memory maintenance and reducing the need for prefrontal participation.
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页码：2315 / +
页数：6
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