Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

被引：978

作者：

Kay, MA ^{[1
]}

Glorioso, JC

Naldini, L

机构：

[1] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[3] Univ Pittsburgh, Dept Mol Genet & Biochem, Pittsburgh, PA USA

[4] Univ Turin, Sch Med, Inst Canc Res & Treatment, Turin, Italy

来源：

NATURE MEDICINE | 2001年 / 7卷 / 01期

关键词：

D O I：

10.1038/83324

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considered by some to be among the simpler forms of life, viruses represent highly evolved natural vectors for the transfer of foreign genetic information into cells. This attribute has led to extensive attempts to engineer recombinant viral vectors for the delivery of therapeutic genes into diseased tissues. While substantial progress has been made, and some clinical successes are over the horizon, further vector refinement and/or development is required before gene therapy will become standard care for any individual disorder.

引用

页码：33 / 40

页数：8

共 129 条

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