Development of the first Bronsted acid assisted enantioselective Bronsted acid catalyzed direct Mannich reaction

被引：89

作者：

Rueping, Magnus ^{[1
]}

Sugiono, Erli ^{[1
]}

Schoepke, Fenja R. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany

来源：

SYNLETT | 2007年 / 09期

关键词：

Mannich reaction; organocatalysis; Bronsted acid; BINOL-phosphate; cooperative catalysis;

D O I：

10.1055/s-2007-980369

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We here describe the development of the first enantioselective Bronsted acid assisted chiral Bronsted acid catalyzed direct Mannich reaction of acetophenone with various aldimines. The re-action proceeds in the presence of a chiral and an achiral Bronsted acid which simultaneously activate the ketone and aldimine to give the corresponding beta-amino ketones with good enantioselectivities and without the necessity of enolate preformation.

引用

页码：1441 / 1445

页数：5

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