Original catalytic synthesis of macrodiolides containing a 1Z,5Z-diene moiety

被引：8
|
作者：
D'yakonov, Vladimir A. [1 ]
Islamov, Ilgiz I. [1 ]
Khusainova, Elvina M. [1 ]
Dzhemilev, Usein M. [1 ]
机构：
[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa 450075, Russia
来源：
MENDELEEV COMMUNICATIONS | 2018年 / 28卷 / 05期
基金：
俄罗斯科学基金会;
关键词：
HUMAN TOPOISOMERASE-I; FATTY-ACIDS; BIOLOGICAL EVALUATION; MACROLIDE; EUSHEARILIDE; INHIBITORS; SPONGE; ALPHA;
D O I：
10.1016/j.mencom.2018.09.017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Macrodiolides containing a 1Z,5Z-diene moiety were obtained with high selectivity (>98%) and in good yields (59-70%) by the Cu(OTf)(2)-catalyzed intermolecular esterification of aliphatic alpha,omega-dicarboxylic acids with tetradeca-5Z,9Z-diene-1,14-diol. This diol was accessed by homocyclomagnesiation of hepta-5,6-dien-1-ol tetrahydropyranyl ether using EtMgBr/Mg reagent system and Cp2TiCl2 catalyst.
引用
收藏
页码：503 / 504
页数：2
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