Dairy Product Consumption Interacts with Glucokinase (GCK) Gene Polymorphisms Associated with Insulin Resistance

被引：10
作者：
Da Silva, Marine S. [1 ,2 ]
Chartrand, Dominic [1 ,2 ]
Vohl, Marie-Claude [3 ,4 ]
Barbier, Olivier [5 ,6 ]
Rudkowska, Iwona [1 ,2 ]
机构：
[1] Laval Univ, CHU Quebec, Res Ctr, Endocrinol & Nephrol, Quebec City, PQ G1V 0A6, Canada
[2] Laval Univ, Fac Med, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada
[3] Laval Univ, Inst Nutr & Funct Foods INAF, Fac Agr, Quebec City, PQ G1V 0A6, Canada
[4] Laval Univ, Sch Nutr, Fac Agr, Quebec City, PQ G1V 0A6, Canada
[5] CHU Quebec, Res Ctr, Lab Mol Pharmacol, Quebec City, PQ G1V, Canada
[6] Laval Univ, Fac Pharm, Quebec City, PQ G1V, Canada
来源：
JOURNAL OF PERSONALIZED MEDICINE | 2017年 / 7卷 / 03期
关键词：
dairy; glucose; insulin sensitivity; nutrigenomics; type; 2; diabetes; BETA-CELL FUNCTION; WHEY-PROTEIN; TYPE-2; PROMOTER; GLUCOSE; RISK; SUSCEPTIBILITY; HYPERGLYCEMIA; EXPRESSION; FOODS;
D O I：
10.3390/jpm7030008
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Dairy product intake and a person's genetic background have been reported to be associated with the risk of type 2 diabetes (T2D). The objective of this study was to examine the interaction between dairy products and genes related to T2D on glucose-insulin homeostasis parameters. A validated food frequency questionnaire, fasting blood samples, and glucokinase (GCK) genotypes were analyzed in 210 healthy participants. An interaction between rs1799884 in GCK and dairy intake on the homeostasis model assessment of insulin resistance was identified. Secondly, human hepatocellular carcinoma cells (HepG2) were grown in a high-glucose medium and incubated with either 1-dairy proteins: whey, caseins, and a mixture of whey and casein; and 2-four amino acids (AA) or mixtures of AA. The expression of GCK-related genes insulin receptor substrate-1 (IRS-1) and fatty acid synthase (FASN) was increased with whey protein isolate or hydrolysate. Individually, leucine increased IRS-1 expression, whereas isoleucine and valine decreased FASN expression. A branched-chain AA mixture decreased IRS-1 and FASN expression. In conclusion, carriers of the A allele for rs1799884 in the GCK gene may benefit from a higher intake of dairy products to maintain optimal insulin sensitivity. Moreover, the results show that whey proteins affect the expression of genes related to glucose metabolism.
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页数：12
相关论文
共 35 条
[1]   Genetics of Type 2 diabetes [J].
Barroso, I .
DIABETIC MEDICINE, 2005, 22 (05) :517-535
[2]   An interaction effect between glucokinase gene variation and carbohydrate intakes modulates the plasma triglyceride response to a fish oil supplementation [J].
Bouchard-Mercier, Annie ;
Rudkowska, Iwona ;
Lemieux, Simone ;
Couture, Patrick ;
Vohl, Marie-Claude .
GENES AND NUTRITION, 2014, 9 (03)
[3]   The Effects of Dairy Components on Energy Partitioning and Metabolic Risk in Mice: A Microarray Study [J].
Bruckbauer, Antje ;
Gouffon, Julia ;
Rekapalli, Bhanu ;
Zemel, Michael B. .
JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS, 2009, 2 (02) :64-77
[4]   Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation [J].
Cormier, Hubert ;
Rudkowska, Iwona ;
Lemieux, Simone ;
Couture, Patrick ;
Julien, Pierre ;
Vohl, Marie-Claude .
GENES AND NUTRITION, 2014, 9 (06)
[5]   Dairy nutrients and their effect on inflammatory profile in molecular studies [J].
Da Silva, Marine S. ;
Rudkowska, Iwona .
MOLECULAR NUTRITION & FOOD RESEARCH, 2015, 59 (07) :1249-1263
[6]   USE OF POLYETHYLENE GLYCOL TO SEPARATE FREE AND ANTIBODY-BOUND PEPTIDE HORMONES IN RADIOIMMUNOASSAYS [J].
DESBUQUOIS, B ;
AURBACH, GD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1971, 33 (05) :732-+
[7]   Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study [J].
Gayoso-Diz, Pilar ;
Otero-Gonzalez, Alfonso ;
Xose Rodriguez-Alvarez, Maria ;
Gude, Francisco ;
Garcia, Fernando ;
De Francisco, Angel ;
Gonzalez Quintela, Arturo .
BMC ENDOCRINE DISORDERS, 2013, 13
[8]   Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies [J].
Gijsbers, Lieke ;
Ding, Eric L. ;
Malik, Vasanti S. ;
de Goede, Janette ;
Geleijnse, Johanna M. ;
Soedamah-Muthu, Sabita S. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2016, 103 (04) :1111-1124
[9]   Glucokinase (GCK) mutations in hyper- and hypoglycemia:: Maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy [J].
Gloyn, AL .
HUMAN MUTATION, 2003, 22 (05) :353-362
[10]   Validity and reproducibility of an interviewer-administered food frequency questionnaire for healthy French-Canadian men and women [J].
Goulet, Julie ;
Nadeau, Genevieve ;
Lapointe, Annie ;
Lamarche, Benoit ;
Lemieux, Simone .
NUTRITION JOURNAL, 2004, 3 (1)
1234