Serum levels of brominated flame retardants (BFRs: PBDE, HBCD) and influence of dietary factors in a population-based study on Swedish adults

被引:51
作者
Bjermo, Helena [1 ]
Aune, Marie [1 ]
Cantillana, Tatiana [1 ]
Glynn, Anders [1 ]
Lind, P. Monica [2 ]
Ridefelt, Peter [3 ]
Darnerud, Per Ola [1 ]
机构
[1] Swedish Natl Food Agcy, Uppsala, Sweden
[2] Uppsala Univ, Occupat & Environm Med, Uppsala, Sweden
[3] Uppsala Univ, Akad Hosp, Clin Med & Pharmacol, Uppsala, Sweden
关键词
Brominated flame retardants; PBDE; HBCD; Serum; Population-based survey; Diet; POLYBROMINATED DIPHENYL ETHERS; MARKET BASKET; EXPOSURE; MOTHERS; TRENDS; TIME; MILK;
D O I
10.1016/j.chemosphere.2016.10.008
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The aim of this study was to investigate associations between serum concentrations of brominated flame retardants and personal characteristics, including diet, in adults participating in a population-based study in Sweden 2010-11. Moreover, observed concentrations were used in a health risk assessment, using published health-based reference values. Serum samples of 170 adult individuals of both sexes were analyzed for 10 PBDE congeners and HBCD by GC-MS. When including concentrations between LOD and LOQ, highest median serum concentration was observed for BDE-153 (1.2 ng/g serum lipid), followed by BDE-209 (0.95 ng/g lipid), BDE-47 (0.49 ng/g lipid) and BDE-100 (0.21 ng/g lipid). Median concentration of HBCD was 0.10 ng/g lipid. A few markedly elevated concentrations of BDE-209, HBCD (77-78 ng/g lipid) and BDE-47 (44 ng/g lipid) were observed. The only statistical significant findings were higher BDE-153 concentrations in men than in women, and positive associations between serum BDE-153 concentrations and consumption of fish (total), beef, mutton and poultry. PBDE concentrations were in accordance with concentrations reported in other European countries but generally lower than those found in North America. Median PBDE serum concentrations observed in adults from Sweden suggest sufficient health protection, when compared with published health-based reference values, although some outliers with high serum concentrations had lower safety margins. (C) 2016 The Authors. Published by Elsevier Ltd.
引用
收藏
页码:485 / 491
页数:7
相关论文
共 30 条
[1]   Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food [J].
Alexander, Jan ;
Benford, Diane ;
Boobis, Alan Raymond ;
Ceccatelli, Sandra ;
Cottrill, Bruce ;
Cravedi, Jean-Pierre ;
Di Domenico, Alessandro ;
Doerge, Daniel ;
Dogliotti, Eugenia ;
Edler, Lutz ;
Farmer, Peter ;
Filipic, Metka ;
Fink-Gremmels, Johanna ;
Furst, Peter ;
Guerin, Thierry ;
Knutsen, Helle Katrine ;
Machala, Miroslav ;
Mutti, Antonio ;
Rose, Martin ;
Schlatter, Josef Rudolf ;
van Leeuwen, Rolaf .
EFSA JOURNAL, 2011, 9 (05)
[2]   Handling Data Below the Limit of Quantification in Mixed Effect Models [J].
Bergstrand, Martin ;
Karlsson, Mats O. .
AAPS JOURNAL, 2009, 11 (02) :371-380
[3]   Brominated flame retardants: Cause for concern? [J].
Birnbaum, LS ;
Staskal, DF .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (01) :9-17
[4]   Fish intake and breastfeeding time are associated with serum concentrations of organochlorines in a Swedish population [J].
Bjermo, Helena ;
Darnerud, Per Ola ;
Lignell, Sanna ;
Pearson, Monika ;
Rantakokko, Panu ;
Nalsen, Cecilia ;
Barbieri, Helene Enghardt ;
Kiviranta, Hannu ;
Lindroos, Anna Karin ;
Glynn, Anders .
ENVIRONMENT INTERNATIONAL, 2013, 51 :88-96
[5]   Polybrominated diphenyl ethers (PBDEs) in foodstuffs:: Human exposure through the diet [J].
Bocio, A ;
Llobet, JM ;
Domingo, JL ;
Corbella, J ;
Teixidó, A ;
Casas, C .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (10) :3191-3195
[6]   Time trends of polybrominated diphenylether (PBDE) congeners in serum of Swedish mothers and comparisons to breast milk data [J].
Darnerud, Per Ola ;
Lignell, Sanna ;
Aune, Marie ;
Isaksson, Martin ;
Cantillana, Tatiana ;
Redeby, Johan ;
Glynn, Anders .
ENVIRONMENTAL RESEARCH, 2015, 138 :352-360
[7]   Polybrominated diphenyl ethers:: Occurrence, dietary exposure, and toxicology [J].
Darnerud, PO ;
Eriksen, GS ;
Jóhannesson, T ;
Larsen, PB ;
Viluksela, M .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2001, 109 :49-68
[8]   Toxic effects of brominated flame retardants in man and in wildlife [J].
Darnerud, PO .
ENVIRONMENT INTERNATIONAL, 2003, 29 (06) :841-853
[9]   An overview of brominated flame retardants in the environment [J].
de Wit, CA .
CHEMOSPHERE, 2002, 46 (05) :583-624
[10]   Temporal trends of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, 1980-2004 [J].
Fangstrom, Britta ;
Athanassiadis, Loannis ;
Odsjo, Tielvar ;
Noren, Koidu ;
Bergman, Ake .
MOLECULAR NUTRITION & FOOD RESEARCH, 2008, 52 (02) :187-193