Early cannabis use and Schizotypal Personality Disorder Symptoms from adolescence to middle adulthood

被引:32
作者
Anglin, Deidre M. [1 ,2 ]
Corcoran, Cheryl M. [3 ]
Brown, Alan S. [3 ]
Chen, Henian [4 ]
Lighty, Quenesha [1 ,2 ]
Brook, Judith S. [5 ]
Cohen, Patricia R. [3 ]
机构
[1] CUNY City Coll, New York, NY 10032 USA
[2] CUNY, Grad Ctr, New York, NY 10021 USA
[3] Columbia Univ, Coll Phys & Surg, New York State Psychiat Inst, Dept Psychiat, New York, NY 10027 USA
[4] Univ S Florida, Tampa, FL 33620 USA
[5] NYU, Sch Med, New York, NY 10003 USA
关键词
Early cannabis use; Schizotypal personality; Longitudinal; GENERAL-POPULATION; SWEDISH CONSCRIPTS; COMMUNITY SAMPLE; SUBSTANCE USE; FOLLOW-UP; PSYCHOSIS; RISK; SCHIZOPHRENIA; ASSOCIATION; STABILITY;
D O I
10.1016/j.schres.2012.01.019
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: While increasing evidence suggests that cannabis use may play a role in the development of schizophrenia in some young people, less is known about the strength and specificity of its relationship to latent schizophrenia liability, i.e., schizotypal personality disorder traits. Aims: Determine the predictive value of cannabis use during childhood and early adolescence on schizotypal personality disorder (SPD) symptoms projecting into adulthood, using a community-based longitudinal cohort from upstate New York. Method: Prospective data from 804 participants was used to determine associations between early cannabis use and later schizotypal symptoms, accounting for important potential confounds (e. g., adolescent schizotypal symptoms). Results: Cannabis use with onset prior to age 14 strongly predicted SPD symptoms in adulthood, independent of early adolescent SPD symptoms, major depression, anxiety disorder, other drug use, and cigarette use. There was no interaction effect of early cannabis use and early adolescent SPD symptoms on SPD symptoms into adulthood. Conclusions: Our data provide further support for a strong association of early cannabis use with the development of symptoms characteristic of schizophrenia spectrum disorders. As with studies in schizophrenia, early SPD symptoms could not fully explain the association of early cannabis use with later schizotypal symptoms. The mechanisms that underlie the association of cannabis use and schizotypal symptoms in a developmental context deserve further exploration. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:45 / 49
页数:5
相关论文
共 41 条
[11]  
Cohen P., 1996, LIFE VALUES ADOLESCE
[12]   Personality disorders in early adolescence and the development of later substance use disorders in the general population [J].
Cohen, Patricia ;
Chen, Henian ;
Crawford, Thomas N. ;
Brook, Judith S. ;
Gordon, Kathy .
DRUG AND ALCOHOL DEPENDENCE, 2007, 88 :S71-S84
[13]   Cannabis Use, First-Episode Psychosis, and Schizotypy: A Summary and Synthesis of Recent Literature [J].
Compton, Michael T. ;
Goulding, Sandra M. ;
Walker, Elaine F. .
CURRENT PSYCHIATRY REVIEWS, 2007, 3 (03) :161-171
[14]   Temporal association of cannabis use with symptoms in individuals at clinical high risk for psychosis [J].
Corcoran, Cheryl M. ;
Kimhy, David ;
Stanford, Arielle ;
Khan, Shamir ;
Walsh, Julie ;
Thompson, Judy ;
Schobel, Scott ;
Harkavy-Friedman, Jill ;
Goetz, Ray ;
Colibazzi, Tiziano ;
Cressman, Victoria ;
Malaspina, Dolores .
SCHIZOPHRENIA RESEARCH, 2008, 106 (2-3) :286-293
[15]  
Costello E.J., 1984, TESTING NIMH DIAGNOS
[16]   Self-reported personality disorder in the children in the community sample: Convergent and prospective validity in late adolescence and adulthood [J].
Crawford, TN ;
Cohen, P ;
Johnson, JG ;
Kasen, S ;
First, MB ;
Gordon, K ;
Brook, JS .
JOURNAL OF PERSONALITY DISORDERS, 2005, 19 (01) :30-52
[17]   Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction [J].
D'Souza, DC ;
Abi-Saab, WM ;
Madonick, S ;
Forselius-Bielen, K ;
Doersch, A ;
Braley, G ;
Gueorguieva, R ;
Cooper, TB ;
Krystal, JH .
BIOLOGICAL PSYCHIATRY, 2005, 57 (06) :594-608
[18]   Schizotypy and nicotine, alcohol, and cannabis use in a non-psychiatric sample [J].
Esterberg, Michelle L. ;
Goulding, Sandra M. ;
McClure-Tone, Erin B. ;
Compton, Michael T. .
ADDICTIVE BEHAVIORS, 2009, 34 (04) :374-379
[19]   Drugs - Cannabis and psychosis [J].
Fergusson, DM ;
Poulton, R ;
Smith, PF ;
Boden, JM .
BRITISH MEDICAL JOURNAL, 2006, 332 (7534) :172-175
[20]  
First M.B., 2016, SCID-5-CV: Structured clinical interview for DSM-5 disorders: Clinician version