microRNAs in chronic kidney disease

被引：51
作者：
Zhao, Hui [1 ]
Ma, Shi-Xing [2 ]
Shang, You-Quan [2 ]
Zhang, Huan-Qiao [2 ]
Su, Wei [2 ]
机构：
[1] Northwest Univ, Fac Life Sci & Med, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China
[2] Baoji Cent Hosp, Dept Nephrol, 8 Jiangtan Rd, Baoji 721008, Shaanxi, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2019年 / 491卷
关键词：
microRNA; Chronic kidney disease; Diabetic nephropathy; Lupus nephritis; Focal segmental glomerulosclerosis; IgA nephropathy; GLUCOSE-INDUCED APOPTOSIS; INDUCED PODOCYTE APOPTOSIS; TUBULAR EPITHELIAL-CELLS; DIABETIC-NEPHROPATHY; LUPUS NEPHRITIS; TGF-BETA/SMAD; MESENCHYMAL TRANSITION; DOWN-REGULATION; EXPRESSION; ACTIVATION;
D O I：
10.1016/j.cca.2019.01.008
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Chronic kidney disease (CKD) results in high morbidity and mortality worldwide causing a huge socioeconomic burden. MicroRNA (miRNA) exert critical regulatory functions by targeting downstream genes and have been associated with many pathophysiologic processes including CKD. In fact, many studies have shown that the expression of various miRNAs was significantly changed in CKD. Current investigations have focused on revealing the relationship between miRNAs and CKD states including diabetic nephropathy, lupus nephritis, focal segmental glomerulosclerosis and IgA nephropathy. In this review, we summarize the latest advances elucidating miRNA involvement in the progression of CKD and demonstrate that miRNAs have the potential to be effective biomarkers and therapeutic targets for subsequent treatment.
引用
收藏
页码：59 / 65
页数：7
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