Challenges for nanomechanical sensors in biological detection

被引：89

作者：

Calleja, Montserrat ^{[1
]}

Kosaka, Priscila M. ^{[1
]}

San Paulo, Alvaro ^{[1
]}

Tamayo, Javier ^{[1
]}

机构：

[1] CSIC, Inst Microelect Madrid, Madrid 28760, Spain

来源：

NANOSCALE | 2012年 / 4卷 / 16期

基金：

欧洲研究理事会;

关键词：

SELF-ASSEMBLED MONOLAYERS; CANTILEVER ARRAY; MICROCANTILEVER ARRAY; RESONATOR ARRAYS; MASS SENSOR; SYSTEMS; READOUT; SINGLE; MICRORESONATORS; SPECTROSCOPY;

D O I：

10.1039/c2nr31102j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanomechanical biosensing relies on changes in the movement and deformation of micro-and nanoscale objects when they interact with biomolecules and other biological targets. This field of research has provided ever-increasing records in the sensitivity of label-free detection but it has not yet been established as a practical alternative for biological detection. We analyze here the latest advancements in the field, along with the challenges remaining for nanomechanical biosensors to become a commonly used tool in biology and biochemistry laboratories.

引用

页码：4925 / 4938

页数：14

共 120 条

[1] Optical sequential readout of microcantilever arrays for biological detection [J].

Alvarez, M ;

Tamayo, J .

SENSORS AND ACTUATORS B-CHEMICAL, 2005, 106 (02) :687-690

[2]

Arcamone J., 2011, IEDM, P2931

[3] Evaporation of femtoliter sessile droplets monitored with nanomechanical mass sensors [J].

Arcamone, Julien ;

Dujardin, Erik ;

Rius, Genuna ;

Perez-Murano, Francesc ;

Ondarcuhu, Thierry .

JOURNAL OF PHYSICAL CHEMISTRY B, 2007, 111 (45) :13020-13027

[4] Comparative advantages of mechanical biosensors [J].

Arlett, J. L. ;

Myers, E. B. ;

Roukes, M. L. .

NATURE NANOTECHNOLOGY, 2011, 6 (04) :203-215

[5] Large-Scale Integration of Nanoelectromechanical Systems for Gas Sensing Applications [J].

Bargatin, I. ;

Myers, E. B. ;

Aldridge, J. S. ;

Marcoux, C. ;

Brianceau, P. ;

Duraffourg, L. ;

Colinet, E. ;

Hentz, S. ;

Andreucci, P. ;

Roukes, M. L. .

NANO LETTERS, 2012, 12 (03) :1269-1274

[6] PHOTOTHERMAL SPECTROSCOPY WITH FEMTOJOULE SENSITIVITY USING A MICROMECHANICAL DEVICE [J].

BARNES, JR ;

STEPHENSON, RJ ;

WELLAND, ME ;

GERBER, C ;

GIMZEWSKI, JK .

NATURE, 1994, 372 (6501) :79-81

[7] Fabrication of a Nanomechanical Mass Sensor Containing a Nanofluidic Channel [J].

Barton, Robert A. ;

Ilic, B. ;

Verbridge, Scott S. ;

Cipriany, Benjamin R. ;

Parpia, Jeevak M. ;

Craighead, Harold G. .

NANO LETTERS, 2010, 10 (06) :2058-2063

[8] A chemical sensor based on a microfabricated cantilever array with simultaneous resonance-frequency and bending readout [J].

Battiston, FM ;

Ramseyer, JP ;

Lang, HP ;

Baller, MK ;

Gerber, C ;

Gimzewski, JK ;

Meyer, E ;

Güntherodt, HJ .

SENSORS AND ACTUATORS B-CHEMICAL, 2001, 77 (1-2) :122-131

[9] Rapid functionalization of cantilever array sensors by inkjet printing [J].

Bietsch, A ;

Zhang, JY ;

Hegner, M ;

Lang, HP ;

Gerber, C .

NANOTECHNOLOGY, 2004, 15 (08) :873-880

[10] Cantilever-like micromechanical sensors [J].

Boisen, Anja ;

Dohn, Soren ;

Keller, Stephan Sylvest ;

Schmid, Silvan ;

Tenje, Maria .

REPORTS ON PROGRESS IN PHYSICS, 2011, 74 (03)

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