Synthesis and characterization of 3-[(2-{(2-(hydrazinocarbonyl)ethyl]sulfanyl}phenyl)amino]propanehydrazide derivatives

A series of 3-[(2-{(2-(hydrazinecarbonyl)ethyl]sulfanyl}pheny)amino]propanehydrazide derivatives containing identically ortho-NH/S-substituted benzene moiety were synthesized. The structure of the obtained compounds was proved by combining elemental analysis, mass spectrometry, and H-1 C-13 NMR spectroscopy. The H-1/C-13 2D (HETCOR), H-1/H-1 2D (COSY), DEPT (C-13), NOE (H-1) NMR methods and molecular modeling (MM2) were used for structure elucidation in more complicated cases. Supplementary sets of resonances, observed in the H-1 and C-13 NMR spectra of the majority of synthesized compounds, are explained in terms of peculiar structural features.