Following disease progression in motor neuron disorders with 3 motor unit number estimation methods

被引：52

作者：

Jacobsen, Anna Bystrup ^{[1
]}

Bostock, Hugh ^{[2
]}

Tankisi, Hatice ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Neurophysiol, Norrebrogade 44, DK-8000 Aarhus C, Denmark

[2] UCL, Inst Neurol, London, England

来源：

MUSCLE & NERVE | 2019年 / 59卷 / 01期

关键词：

ALS Functional Rating Scale; amyotrophic lateral sclerosis; follow-up study; MScan; motor unit loss; MUNE; motor unit number estimation; MUNIX; multiple-point stimulation; AMYOTROPHIC-LATERAL-SCLEROSIS; MULTIPLE POINT STIMULATION; INDEX MUNIX; REPRODUCIBILITY; DIAGNOSIS; MUSCLES;

D O I：

10.1002/mus.26304

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction The objective of this study was to evaluate a recently developed motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), as a measure of disease progression in amyotrophic lateral sclerosis (ALS) compared with compound muscle action potential (CMAP) amplitude and 2 traditional MUNE methods. Methods ALS patients were evaluated clinically using the ALS Functional Rating Scale-Revised (ALSFRS-R). MScan, multiple-point stimulation MUNE (MPS), and motor unit number index (MUNIX) were performed in the abductor pollicis brevis (APB) muscle at baseline (27 patients), 4 months (23 patients), and 8 months (16 patients). Results Of the 5 measures, MScan registered the largest decline (8.7% per month), compared with MPS (3.4%), MUNIX (4.8%), CMAP amplitude (2.0%), and ALSFRS-R (1.9%). Only MScan and ALSFRS-R registered significant decrements over 4 and 8 months. Discussion MScan may be useful as a sensitive, objective tool for quantifying motor unit loss in ALS. Muscle Nerve 59:82-87, 2019

引用

页码：82 / 87

页数：6

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