Recurrent granulomatous cheilitis associated with Crohn's disease successfully treated with ustekinumab: case report and literature review

被引：8

作者：

Taxonera, Carlos ^{[1
]}

Alba, Cristina ^{[1
]}

Colmenares, Michel ^{[1
]}

Olivares, David ^{[1
]}

Rey, Enrique ^{[1
]}

机构：

[1] Inst Invest Hosp Clin San Carlos IdISSC, Gastroenterol, Inflammatory Bowel Dis Unit, Hosp Clin San Carlo, Madrid, Spain

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2020年 / 13卷

关键词：

adalimumab; Crohn's disease; granulomatous cheilitis; infliximab; orofacial granulomatosis; ustekinumab; vedolizumab; MELKERSSON-ROSENTHAL-SYNDROME; OROFACIAL GRANULOMATOSIS; INFLIXIMAB; THERAPY; MANIFESTATIONS; CHILDREN;

D O I：

10.1177/1756284820934327

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Granulomatous cheilitis, characterized by persistent inflammation of the lips and a granulomatous histology, is sometimes associated with Crohn's disease and is a therapeutic challenge. Reported evidence indicates treatment with an anti-TNF agent (mainly infliximab) is the most recommended therapeutic option after failure of conventional treatments. The clinical case reported the effectiveness of ustekinumab, a monoclonal antibody against interleukins 12/23, to induce the remission of severe and recurrent granulomatous cheilitis in a patient with Crohn's disease.

引用

页数：6

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