Reply to Comment on 'Linear energy transfer incorporated intensity modulated proton therapy optimization'

被引：0
|
作者：
Cao, Wenhua [1 ]
Khabazian, Azin [2 ]
Yepes, Pablo [1 ,3 ]
Lim, Gino [2 ]
Poenisch, Falk [1 ]
Grosshans, David [4 ]
Mohan, Radhe [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA
[2] Univ Houston, Dept Ind Engn, Houston, TX 77204 USA
[3] Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2019年 / 64卷 / 05期
关键词：
intensity modulated proton therapy; linear energy tranfer; optimization; GLOBAL OPTIMIZATION; SUM; ALGORITHM;
D O I：
10.1088/1361-6560/aaff72
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this reply we present additional description of our linear model for LET optimization in response to the comments by Dr Gorissen. We clarify that this model cannot guarantee global optimal solutions to the sum-of-fractions problem. Based on our data, it could be used to optimize LET efficiently while dose constraints are maintained.
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