Intraoperative Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma

被引:26
作者
Lee, Yu-Jin [1 ]
Krishnan, Giri [1 ,2 ]
Nishio, Naoki [1 ]
van den Berg, Nynke S. [1 ]
Lu, Guolan [1 ]
Martin, Brock A. [3 ]
van Keulen, Stan [1 ]
Colevas, Alexander D. [4 ]
Kapoor, Shrey [1 ]
Liu, Jonathan T. C. [5 ,6 ,7 ]
Rosenthal, Eben L. [1 ,8 ]
机构
[1] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Stanford, CA 94305 USA
[2] Univ Adelaide, Dept Otolaryngol Head & Neck Surg, Adelaide, SA, Australia
[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Dept Med, Div Oncol, Stanford, CA 94305 USA
[5] Univ Washington, Dept Mech Engn, Seattle, WA 98195 USA
[6] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA
[7] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[8] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
Fluorescence-guided surgery; near-infrared imaging; sentinel margin; SURGICAL MARGINS; RESECTION MARGIN; IDENTIFICATION; SPECIFICITY; NAVIGATION; SURVIVAL; DISEASE; FIELD;
D O I
10.1002/lary.28822
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The rate of positive margins in head and neck cancers has remained stagnant over the past three decades and is consistently associated with poor overall survival. This suggests that significant improvements must be made intraoperatively to ensure negative margins. We discuss the important role of fluorescence imaging to guide surgical oncology in head and neck cancer. This review includes a general overview of the principles of fluorescence, available fluorophores used for fluorescence imaging, and specific clinical applications of fluorescence-guided surgery, as well as challenges and future directions in head and neck surgical oncology.Laryngoscope, 2020
引用
收藏
页码:529 / 534
页数:6
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