Immune responses after acute ischemic stroke or myocardial infarction

被引：49

作者：

Haeusler, Karl Georg ^{[1
,2
]}

Schmidt, Wolf U. H. ^{[1
,2
]}

Foehring, Fabian ^{[1
]}

Meisel, Christian ^{[3
]}

Guenther, Christoph ^{[4
]}

Brunecker, Peter ^{[2
]}

Kunze, Claudia ^{[2
]}

Helms, Thomas ^{[1
]}

Dirnagl, Ulrich ^{[2
]}

Volk, Hans-Dieter ^{[3
]}

Villringer, Arno ^{[2
,5
,6
,7
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, D-12200 Berlin, Germany

[2] Charite, Ctr Stroke Res, D-13353 Berlin, Germany

[3] Charite Univ Med Berlin, Dept Med Immunol, D-12200 Berlin, Germany

[4] Charite Univ Med Berlin, Dept Cardiol, D-12200 Berlin, Germany

[5] Max Planck Inst Neuropsychol Forsch, D-04103 Leipzig, Germany

[6] Univ Hosp, Leipzig, Germany

[7] Humboldt Univ, Mind & Brain Inst, Berlin Sch Mind & Brain, D-10099 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2012年 / 155卷 / 03期

关键词：

Acute ischemic stroke; Acute myocardial infarction; Human; Immunodepression; HLA-DR; ACUTE CORONARY SYNDROMES; BLOOD-CELL COUNT; CIRCULATING MONOCYTES; ANGIOGRAPHIC FINDINGS; ACTIVATION; IMMUNODEPRESSION; INFLAMMATION; INFECTIONS; IMBALANCE; DIAGNOSIS;

D O I：

10.1016/j.ijcard.2010.10.053

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: We recently demonstrated an immediate immunodepressive state after acute ischemic stroke in humans. Methods: In the present study, we prospectively analyzed immune responses in patients with middle cerebral artery stroke (n = 20), acute myocardial infarction (n = 20) and healthy controls (n = 20, also matched for age and gender). Results: Compared to controls, a rapid depression of monocytic HLA-DR expression and a defective lymphocytic IFN-gamma production was obvious after ischemic stroke or myocardial infarction, while total counts of leukocytes and monocytes were significantly higher after myocardial infarction. A T cell-mediated lymphopenia was accentuated in patients with severe stroke, obviously predisposing these patients for nosocomial infections. Conclusions: Our data reveal an immediate and to some extent differential suppression of cell-mediated immune responses after ischemic stroke or myocardial infarction respectively. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：372 / 377

页数：6

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