The efferent medial olivocochlear-hair cell synapse

被引：58

作者：

Belen Elgoyhen, Ana ^{[1
,2
]}

Katz, Eleonora ^{[1
,3
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Inst Invest Ingn Genet & Biol Mol, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Med, Tercera Catedra Farmacol, RA-1428 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 2012年 / 106卷 / 1-2期

关键词：

Hair cells; Nicotinic receptors; alpha 9 and alpha 10 Nicotinic receptors; Synaptic plasticity; Prestin; Cochlea; SK channels; NICOTINIC ACETYLCHOLINE-RECEPTOR; CA2+-ACTIVATED K+ CHANNELS; GENE-RELATED PEPTIDE; CHOLINERGIC-RECEPTOR; SMALL-CONDUCTANCE; ACH RECEPTOR; TRANSMITTER RELEASE; SK2; CHANNELS; PHARMACOLOGICAL CHARACTERIZATION; DEVELOPMENTAL REGULATION;

D O I：

10.1016/j.jphysparis.2011.06.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of alpha 9 and alpha 10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：47 / 56

页数：10

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