SYNTHESIS AND ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW PYRIMIDIN-2(5H)-ONE/THIONE AND 4H-CHROMEN-4-ONE DERIVATIVES

被引：3

作者：

Bansode, T. N. ^{[1
]}

Ansari, R. M. ^{[1
]}

Gawale, Y. K. ^{[1
]}

机构：

[1] BNN Coll, Dept Chem, Bhiwani 421305, Thane MS, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 45卷 / 06期

关键词：

Chromones; pyrimidinone/thiones; synthesis; antimicrobial properties; ANTIMICROBIAL ACTIVITY; AGENTS; FLAVONOIDS; CHALCONES;

D O I：

10.1007/s11094-011-0635-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new synthesis of 2-substituted-4H-chromen-4-ones (IVa-c) and 4-(2-hydroxyphenyl)-6-substituted pyrimidin- 2(5H)-one/thiones (Va - Vc)/(VIa - VIc) derivatives is reported. First, benzoyloxy esters are converted into their 1,3-diones (IIIa - IIIc) by using dry KOH in pyridine via the Baker - Venkataraman transformation reaction. Then, 1,3-diones thus obtained are cyclised into 2-substituted-4H-chromen-4-ones (IVa - IVc) and 4-(2-hydroxyphenyl)-6-substituted pyrimidin-2(5H)-one/thiones (Va - Vc)/(VIa - VIc) by refluxing in acetic acid and urea/thiourea in ethanol, respectively. The newly synthesized compounds were characterized by IR, H-1 NMR, and mass spectroscopy and elemental analysis and tested for their antibacterial and antifungal activity.

引用

页码：366 / 368

页数：3

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