Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor

被引：10

作者：

Aoki, Y ^{[1
]}

Kodama, S ^{[1
]}

Kurata, H ^{[1
]}

Kase, H ^{[1
]}

Tanaka, K ^{[1
]}

机构：

[1] Niigata Univ, Sch Med, Dept Obstet & Gynecol, Niigata 9518510, Japan

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1999年 / 47卷 / 03期

关键词：

placental site trophoblastic tumor; high-dose chemotherapy; peripheral blood stem cell transplantation;

D O I：

10.1159/000010081

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Placental site trophoblastic tumor(PSTT) is a rare form of gestational trophoblastic disease. The metastatic and refractory cases have a very poor prognosis. To our knowledge, this is the first report of the application of high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) for the treatment of refractory metastatic PSTT. A 36-year-old woman had a metastatic PSTT refractory to several:lines of chemotherapy. She was treated with high dose of carboplatin and etoposide with:autologous PBSCT. She showed only a temporary response to high-dose chemotherapy with PBSCT support and died of disease.

引用

页码：214 / 216

页数：3

共 10 条

[1] HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS PERIPHERAL STEM-CELL SUPPORT IN ADVANCED OVARIAN-CANCER [J].

BENEDETTIPANICI, P ;

GREGGI, S ;

SCAMBIA, G ;

SALERNO, MG ;

MENICHELLA, G ;

PIERELLI, L ;

FODDAI, ML ;

BIZZI, B ;

MANCUSO, S .

ANNALS OF MEDICINE, 1995, 27 (01) :133-138

[2]

BESIEN K, 1997, GYNECOL ONCOL, V65, P366

[3] SURGERY AND CHEMOTHERAPY IN THE MANAGEMENT OF PLACENTAL SITE TUMOR [J].

DESSAU, R ;

RUSTIN, GJS ;

DENT, J ;

PARADINAS, FJ ;

BAGSHAWE, KD .

GYNECOLOGIC ONCOLOGY, 1990, 39 (01) :56-59

[4] PLACENTAL SITE TROPHOBLASTIC TUMOR (TROPHOBLASTIC PSEUDOTUMOUR) - A STUDY OF 4 CASES REQUIRING HYSTERECTOMY INCLUDING ONE FATAL CASE [J].

ECKSTEIN, RP ;

PARADINAS, FJ ;

BAGSHAWE, KD .

HISTOPATHOLOGY, 1982, 6 (02) :211-226

[5]

FINKLER NJ, 1988, OBSTET GYNECOL, V71, P854

[6]

HOPKINS M, 1985, OBSTET GYNECOL S, V66, P95

[7] Recurrent placental site trophoblastic tumor of the uterus: Clinical, pathologic, ultrastructural, and DNA fingerprint study [J].

Kodama, S ;

Kase, H ;

Aoki, Y ;

Yahata, T ;

Tanaka, K ;

Motoyama, T ;

Dewa, K .

GYNECOLOGIC ONCOLOGY, 1996, 60 (01) :89-93

[8]

KURMAN RJ, 1976, CANCER, V38, P1214, DOI 10.1002/1097-0142(197609)38:3<1214::AID-CNCR2820380323>3.0.CO

[9]

2-J

[10] PLACENTAL SITE TROPHOBLASTIC TUMOR IN A POSTMENOPAUSAL WOMAN [J].

MCLELLAN, R ;

BUSCEMA, J ;

CURRIE, JL ;

WOODRUFF, JD .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1991, 95 (05) :670-675

← 1 →