Adipokines and insulin resistance during pregnancy

被引：105
|
作者：
Bertha Zavalza-Gomez, Ana [1 ]
Anaya-Prado, Roberto [1 ]
Rosa Rincon-Sanchez, Ana [1 ]
Miguel Mora-Martinez, Jose [1 ]
机构：
[1] Univ Guadalajara, Inst Chron & Degenerat Dis, CUCS, Guadalajara 44430, Jalisco, Mexico
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2008年 / 80卷 / 01期
关键词：
adipokines; pregnancy and insulin resistance;
D O I：
10.1016/j.diabres.2007.12.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Normal pregnancy has been characterized as a "diabetogenic state". On the other hand, the adipose tissue is now considered an active organ, capable of secreting substances such as adipokines, which may play a role in the pathogenesis of insulin resistance. Resistin, leptin serum and placental levels increase as pregnancy progresses, which is in contrast to levels of adiponectin. These levels correlate with the state of reduced insulin sensitivity often developed in the latter stages of pregnancy. The objective of this article is to review recent advances in our understanding of adipokines and insulin resistance during pregnancy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：8 / 15
页数：8
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