Spectral karyotype analysis of T-cell acute leukemia

被引:56
作者
Rowley, JD [1 ]
Reshmi, S [1 ]
Carlson, K [1 ]
Roulston, D [1 ]
机构
[1] Univ Chicago, Med Ctr, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA
关键词
D O I
10.1182/blood.V93.6.2038.406a32_2038_2042
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Analysis of 15 cases of T-cell acute lymphoblastic leukemia with spectral karyotyping (SKY), which can identify all chromosomes simultaneously, clarified the chromosome rearrangements in 3 cases and confirmed them in 11 others; no abnormal cells were identified in 1 case, which had only 10% abnormal cells. Five of the latter cases had a normal karyotype. Thus, the use of SKY substantially improves the precision of karyotype analysis of malignant cells, which in turn leads to a more accurate assessment of the genotypic abnormalities in those cells. (C) 1999 by The American Society of Hematology.
引用
收藏
页码:2038 / 2042
页数:5
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