Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report

被引：11

作者：

Shier, Amr ^{[1
]}

Abdelrazek, Mohamed ^{[2
]}

Soliman, Ashraf ^{[3
,4
]}

De Sanctis, Vincenzo ^{[5
]}

Elsayed, Ahmed ^{[6
]}

Abdulla, Mohamed ^{[7
]}

Mohamed, Shehab ^{[7
]}

Yassin, Khadra ^{[7
]}

Bila, Ilham ^{[8
]}

Yassin, Mohamed ^{[7
]}

机构：

[1] Hamad Gen Hosp Doha, Dept Med Educ, Doha, Qatar

[2] Hamad Gen Hosp Doha, Dept Radiol, Doha, Qatar

[3] Hamad Gen Hosp Doha, Dept Pediat, Div Endocrinol, Doha, Qatar

[4] Alexandria Univ, Dept Pediat, Div Endocrinol, Childrens Hosp, Alexandria, Egypt

[5] Quisisana Hosp, Pediat & Adolescent Outpatient Clin, Ferrara, Italy

[6] Hamad Gen Hosp Doha, Dept Orthoped Surg, Doha, Qatar

[7] Hamad Gen Hosp Doha, Hematol Sect Med Oncol NCCCR, Doha, Qatar

[8] Hamad Gen Hosp Doha, Dept Pediat, Doha, Qatar

来源：

CASE REPORTS IN ONCOLOGY | 2020年 / 13卷 / 01期

关键词：

Sickle cell disease; Avascular necrosis of bone; Hyperbaric oxygen; BONE-MARROW EDEMA; FEMORAL-HEAD; NATURAL-HISTORY; NECROSIS; PATHOPHYSIOLOGY; MANAGEMENT; PAIN;

D O I：

10.1159/000506330

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Hyperbaric oxygen (HBO) therapy is a mode of treatment in which the patient is exposed to very high arterial and tissue oxygen pressure, during multiple sessions. It has been used as primary or adjunctive therapy for a variety of medical disorders, including necrotizing infection and sickle cell crisis. Case Report: In this case series, 3 patients with SCD and avascular necrosis were treated with 15-40 sessions of HBO and were assessed 6-12 months by MRI after treatment. They showed different clinical outcomes and MRI changes. Conclusion: We concluded that HBO can result in some subjective improvement, especially in early stages. Further studies on severe cases are needed.

引用

页码：365 / 372

页数：8

共 28 条

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