Gadolinium(III)-fluorescein complex as a dual modal probe for MRI and fluorescence zinc sensing

被引：32

作者：

Dong, Dapeng ^{[1
]}

Jing, Xu ^{[1
]}

Zhang, Xiaolin ^{[1
]}

Hu, Xiaoyue ^{[1
]}

Wu, Yanyan ^{[1
]}

Duan, Chunying ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chemosensor; Zn2+; Fluorescence; MRI; CONTRAST AGENTS; PARACEST AGENTS; CHARGE-TRANSFER; IN-VITRO; SENSOR; DESIGN; ZN2+; RELAXIVITY; IONS; NEUROBIOLOGY;

D O I：

10.1016/j.tet.2011.10.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A bimodal imaging Gd-Zpy probe based on magnetic resonance imaging and fluorescence sensing has been synthesized and characterized. Gd-Zpy features a bright green emission and a turn-on fluorescent response manner with high sensitivity for Zn2+ in aqueous solution and is able to luminescent imaging intracellular Zn2+ levels within living cells. It exhibits a 130% increase of the longitudinal relaxation time and a 115% increase of transverse relaxive time upon addition of Zn2+. The results demonstrated that the incorporating of the fluorescein dye having the efficient chelators within a high-spin Gd3+ system was a powerful approach to achieve dual modal probes for MRI and fluorescence sensing. (C) 2011 Published by Elsevier Ltd.

引用

页码：306 / 310

页数：5

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