Preparation and Evaluation of Modified Release Zidovudine Tablets

被引：0

作者：

Bicheri, Maria T. L. ^{[1
]}

Chaud, Marco V. ^{[1
]}

Goncalves, Marcos M. ^{[2
]}

Vila, Marta M. D. C. ^{[1
,2
]}

机构：

[1] Univ Sorocaba, Postgrad Programs Pharmaceut Sci, BR-18023000 Sorocaba, SP, Brazil

[2] Univ Estadual Campinas, Univ Campinas, Inst Chem, Cidade Univ Zeferino Vaz, Campinas, SP, Brazil

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2011年 / 30卷 / 08期

关键词：

Hydroxypropyl methylcellulose; Modified release; Zidovudine;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zidovudine is a drug used for the treatment of AIDS. The objective of this work was to prepare tablets for modified release of zidovudine. Hydroxypropyl methylcellulose HPMC K100LV and HPMC K4M at 1250 %, 18.75 % and 25.00 % were used. The tablets produced with 12.50 % of HPMC reached 100 % of the zidovudine release in 6 hours, while those produced with 18.75 and 25.00 %, released 24 h, following the Higuchi and First Order kinetic models, respectively. The calculated release exponent pointed out that formulations follow the anomalous type of release mechanism, with a combined phenomena of diffusion and erosion.

引用

页码：1512 / 1518

页数：7

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