Progeria, rapamycin and normal aging: recent breakthrough

被引：41
作者：
Blagosklonny, Mikhail V. [1 ]
机构：
[1] Roswell Pk Canc Inst, Dept Cell Stress Biol, BLSC, Buffalo, NY 14263 USA
来源：
AGING-US | 2011年 / 3卷 / 07期
关键词：
rapamycin; aging; progeria; senescence; autophagy; obesity; HUTCHINSON-GILFORD-PROGERIA; EXTENDS LIFE-SPAN; ONCOGENE-INDUCED SENESCENCE; HUMAN-DIPLOID FIBROBLASTS; HEMATOPOIETIC STEM-CELLS; DNA-DAMAGE RESPONSES; PROTEIN S6 KINASE; CELLULAR SENESCENCE; LAMIN-A; TELOMERE LENGTH;
D O I：
10.18632/aging.100352
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A recent discovery that rapamycin suppresses a pro-senescent phenotype in progeric cells not only suggests a non-toxic therapy for progeria but also implies its similarity with normal aging. For one, rapamycin is also known to suppress aging of regular human cells. Here I discuss four potential scenarios, comparing progeria with both normal and accelerated aging. This reveals further indications of rapamycin both for accelerated aging in obese and for progeria.
引用
收藏
页码：685 / 691
页数：7
相关论文
共 134 条
  • [1] Chemokine signaling via the CXCR2 receptor reinforces senescence
    Acosta, Juan C.
    O'Loghlen, Ana
    Banito, Ana
    Guijarro, Maria V.
    Augert, Arnaud
    Raguz, Selina
    Fumagalli, Marzia
    Da Costa, Marco
    Brown, Celia
    Popov, Nikolay
    Takatsu, Yoshihiro
    Melamed, Jonathan
    di Fagagna, Fabrizio d'Adda
    Bernard, David
    Hernando, Eva
    Gil, Jesus
    [J]. CELL, 2008, 133 (06) : 1006 - 1018
  • [2] Differential localization of ATM is correlated with activation of distinct downstream signaling pathways
    Alexander, Angela
    Walker, Cheryl L.
    [J]. CELL CYCLE, 2010, 9 (18) : 3685 - 3686
  • [3] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS
    ALLSOPP, RC
    VAZIRI, H
    PATTERSON, C
    GOLDSTEIN, S
    YOUNGLAI, EV
    FUTCHER, AB
    GREIDER, CW
    HARLEY, CB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10114 - 10118
  • [4] Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
    Anisimov, Vladimir N.
    Zabezhinski, Mark A.
    Popovich, Irina G.
    Piskunova, Tatiana S.
    Semenchenko, Anna V.
    Tyndyk, Margarita L.
    Yurova, Maria N.
    Antoch, Marina P.
    Blagosklonny, Mikhail V.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) : 2092 - 2097
  • [5] mTOR regulates memory CD8 T-cell differentiation
    Araki, Koichi
    Turner, Alexandra P.
    Shaffer, Virginia Oliva
    Gangappa, Shivaprakash
    Keller, Susanne A.
    Bachmann, Martin F.
    Larsen, Christian P.
    Ahmed, Rafi
    [J]. NATURE, 2009, 460 (7251) : 108 - U124
  • [6] Reversal of human cellular senescence:: roles of the p53 and p16 pathways
    Beauséjour, CM
    Krtolica, A
    Galimi, F
    Narita, M
    Lowe, SW
    Yaswen, P
    Campisi, J
    [J]. EMBO JOURNAL, 2003, 22 (16) : 4212 - 4222
  • [7] Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
    Benson, Erica K.
    Lee, Sam W.
    Aaronson, Stuart A.
    [J]. JOURNAL OF CELL SCIENCE, 2010, 123 (15) : 2605 - 2612
  • [8] Rapamycin alleviates toxicity of different aggregate-prone proteins
    Berger, Z
    Ravikumar, B
    Menzies, FM
    Oroz, LG
    Underwood, BR
    Pangalos, MN
    Schmitt, I
    Wullner, U
    Evert, BO
    O'Kane, CJ
    Rubinsztein, DC
    [J]. HUMAN MOLECULAR GENETICS, 2006, 15 (03) : 433 - 442
  • [9] MicroRNAs miR-146a/b negatively modulate the senescence associated inflammatory mediators IL-6 and IL-8
    Bhaumik, Dipa
    Scott, Gary K.
    Schokrpur, Shiruyeh
    Patil, Christopher K.
    Orjalo, Arturo V.
    Rodier, Francis
    Lithgow, Gordon J.
    Campisi, Judith
    [J]. AGING-US, 2009, 1 (04): : 402 - 411
  • [10] Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
    Bjedov, Ivana
    Toivonen, Janne M.
    Kerr, Fiona
    Slack, Cathy
    Jacobson, Jake
    Foley, Andrea
    Partridge, Linda
    [J]. CELL METABOLISM, 2010, 11 (01) : 35 - 46
12345678910