Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

被引：141

作者：

Tjwa, Marc ^{[1
,2
]}

Bellido-Martin, Lola ^{[3
]}

Lin, Yuan ^{[5
]}

Lutgens, Esther ^{[4
]}

Plaisance, Stephane ^{[1
,2
]}

Bono, Francoise ^{[6
]}

Delesque-Touchard, Nathalie ^{[6
]}

Herve, Caroline ^{[6
]}

Moura, Rute ^{[7
]}

Billiau, An D. ^{[5
]}

Aparicio, Cristina ^{[3
,8
]}

Levi, Marcel ^{[1
,2
]}

Daemen, Mat ^{[4
]}

Dewerchin, Mieke ^{[1
,2
]}

Lupu, Florea ^{[9
]}

Arnout, Jef ^{[7
]}

Herbert, Jean-Marc ^{[6
]}

Waer, Mark ^{[5
]}

de Frutos, Pablo Garcia ^{[3
,8
]}

DahlbAck, Bjoern ^{[8
]}

Carmeliet, Peter ^{[1
,2
]}

Hoylaerts, Marc F. ^{[7
]}

Moons, Lieve ^{[1
,2
]}

机构：

[1] Katholieke Univ Leuven, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

[2] Flanders Inst Biotechnol VIB, Dept Transgene Technol & Gene Therapy, Louvain, Belgium

[3] CSIC, IDIBAPS, IIBB, Barcelona, Spain

[4] Univ Maastricht, Dept Pathol, Maastricht, Netherlands

[5] Katholieke Univ Leuven, Lab Expt Transplantat, Louvain, Belgium

[6] Cardiovasc Thrombosis Res Dept, Toulouse, France

[7] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Louvain, Belgium

[8] Lund Univ, Dept Clin Chem, Malmo, Sweden

[9] Oklahoma Med Res Fdn, Cardiovasc Res Program, Oklahoma City, OK 73104 USA

来源：

BLOOD | 2008年 / 111卷 / 08期

关键词：

D O I：

10.1182/blood-2007-05-089565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

引用

页码：4096 / 4105

页数：10

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