Chordoid Gliomas of the Third Ventricle Share TTF-1 Expression With Organum Vasculosum of the Lamina Terminalis

被引：44

作者：

Bielle, Franck ^{[1
,5
,6
,7
,8
]}

Villa, Chiara ^{[9
,10
]}

Giry, Marine ^{[5
,6
,7
,8
]}

Bergemer-Fouquet, Anne-Marie ^{[11
]}

Polivka, Marc ^{[4
]}

Vasiljevic, Alexandre ^{[12
]}

Aubriot-Lorton, Marie-Helene ^{[13
]}

Bernier, Michele ^{[10
]}

Lechapt-Zalcman, Emmanuele ^{[14
,15
]}

Viennet, Gabriel ^{[16
]}

Sazdovitch, Veronique ^{[1
]}

Duyckaerts, Charles ^{[1
,5
,6
,7
,8
]}

Sanson, Marc ^{[2
,5
,6
,7
,8
]}

Figarella-Branger, Dominique ^{[17
,18
]}

Mokhtari, Karima ^{[1
,3
,5
,6
,7
,8
]}

机构：

[1] Hop La Pitie Salpetriere, Neuropathol Dept Raymond Escourolle, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, AP HP, Neurol Mazarin Dept 2, F-75013 Paris, France

[3] Hop La Pitie Salpetriere, Onconeurotek, F-75013 Paris, France

[4] Hop Lariboisiere, AP HP, Dept Pathol, F-75475 Paris, France

[5] Univ Paris 06, Sorbonne Univ, UM 75, Paris, France

[6] INSERM, U1127, Paris, France

[7] CNRS, UMR 7225, ICM, Paris, France

[8] Univ Paris 05, Brain & Spine Inst, Paris, France

[9] Univ Paris 05, INSERM, Inst Cochin, U1016, Paris, France

[10] Hop Foch, Dept Anat & Cytol Pathol, Suresnes, France

[11] CHRU Tours, Dept Pathol, Hop Bretonneau, Tours, France

[12] Hosp Civils Lyon, Pathol & Neuropathol Dept, Ctr Biol & Pathol Est, Grp Hosp Est, Bron, France

[13] CHU, Plateau Tech Biol, Dept Pathol, Dijon, France

[14] Caen Univ Hosp, Dept Pathol, Caen, France

[15] CNRS, UMR ISTCT CERVOxy Grp 6301, Caen, France

[16] CHU Besancon, Dept Pathol, F-25030 Besancon, France

[17] CHU, AP HM, Pathol & Neuropathol Dept, Timone, France

[18] Aix Marseille Univ, INSERM, U911, Marseille, France

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 2015年 / 39卷 / 07期

关键词：

TTF-1; chordoid glioma of the third ventricle; lamina terminalis; circumventricular organs; RENOP; THYROID TRANSCRIPTION FACTOR-1; BRAIN; MUTATION; TUMORS; ORIGIN; LUNG; MORPHOGENESIS; VARIANTS; LOCATION; SUBTYPES;

D O I：

10.1097/PAS.0000000000000421

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Chordoid glioma of the third ventricle (CG3V) is a rare tumor developing in a stereotyped localization. It has been related to the circumventricular organ of the lamina terminalis, in the anterior part of the third ventricle, but its oncogenesis is poorly understood. TTF-1 transcription factor is involved in the development and adult physiology of the ventral forebrain. We studied the histopathologic and immunohistochemical features of a multicentric series of 17 cases of CG3V. We described additional histologic patterns (solid, fibrosing, and fusiform) to the typical chordoid pattern. TTF-1 was constantly expressed in CG3V, as in developing and adult lamina terminalis. The anti-TTF-1 SPT24 clone was more sensitive than the 8G7G3/1 clone. No mutation of IDH1 R132, IDH2 R172, or BRAF V600 codons was found. We showed TTF-1 as a useful marker for the diagnosis of CG3V and the understanding of its oncogenesis.

引用

页码：948 / 956

页数：9

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