Isolation and identification of a common intermediate produced by blocked mutants from β-rhodomycin and daunomycin producers

被引：3

作者：

Miyamoto, Y

Oyabu, T

Johdo, O

Nagamatsu, Y

Yoshimoto, A

机构：

[1] Hiroshima Univ, Fac Appl Biol Sci, Higashihiroshima 7390046, Japan

[2] Mercian Corp, Cent Res Labs, Fujisawa, Kanagawa 2510057, Japan

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1998年 / 86卷 / 06期

关键词：

maggiemycin; anthracyclinone intermediate; anthracycline precursor; beta-rhodomycin biosynthesis; beta-rhodomycin-blocked mutant;

D O I：

10.1016/S0922-338X(99)80017-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biosynthetically blocked mutants isolated from the beta-rhodomycin-producing Streptomyces violaceus A262 strain SC-7 and daunomycin-producing Streptomyces sp. D788 strain G1-1 were found to accumulate maggiemycin in their culture broths. Bioconversion tests using mutants that did not produce these antibiotics also proved that maggiemycin is a common precursor in the biosynthesis of beta-rhodomycin and daunomycin.

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收藏

页码：611 / 613

页数：3

相关论文

共 10 条

[1] COSMOMYCIN-D, A NEW ANTHRACYCLINE ANTIBIOTIC [J].

ANDO, T ;

HIRAYAMA, K ;

TAKAHASHI, R ;

HORINO, I ;

ETOH, Y ;

MORIOKA, H ;

SHIBAI, H ;

MURAI, A .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (01) :259-262

[2] ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .1. ISOLATION OF ANTIBIOTIC-BLOCKED MUTANTS FROM STREPTOMYCES-VIOLACEUS A262 [J].

JOHDO, O ;

ISHIKURA, T ;

YOSHIMOTO, A ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1991, 44 (10) :1110-1120

[3] ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .2. NEW ANTHRACYCLINE EPELMYCINS PRODUCED BY A BLOCKED MUTANT STRAIN SU2-730 [J].

JOHDO, O ;

WATANABE, Y ;

ISHIKURA, T ;

YOSHIMOTO, A ;

NAGANAWA, H ;

SAWA, T ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1991, 44 (10) :1121-1129

[4]

KATSUTA Y, 1995, J FAC APPL BIOL SCI, V34, P33

[5] MAGGIEMYCIN AND ANHYDROMAGGIEMYCIN - 2 NOVEL ANTHRACYCLINONE ANTITUMOR ANTIBIOTICS - ISOLATION, STRUCTURES, PARTIAL SYNTHESIS AND BIOLOGICAL PROPERTIES [J].

PANDEY, RC ;

TOUSSAINT, MW ;

MCGUIRE, JC ;

THOMAS, MC .

JOURNAL OF ANTIBIOTICS, 1989, 42 (11) :1567-1577

[6]

UCHIDA T, 1983, J ANTIBIOT, V36, P1080, DOI 10.7164/antibiotics.36.1080

[7] BIOSYNTHESIS OF DAUNOMYCINONE FROM AKLAVINONE AND EPSILON-RHODOMYCINONE [J].

YOSHIMOTO, A ;

OKI, T ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1980, 33 (10) :1199-1201

[8] ANTHRACYCLINE METABOLITES FROM BAUMYCIN-PRODUCING STREPTOMYCES SP D788 .1. ISOLATION OF ANTIBIOTIC-BLOCKED MUTANTS AND THEIR CHARACTERIZATION [J].

YOSHIMOTO, A ;

JOHDO, O ;

FUJII, S ;

KUBO, K ;

NISHIDA, H ;

OKAMOTO, R ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (08) :1255-1267

[9] ANTHRACYCLINE METABOLITES FROM BAUMYCIN-PRODUCING STREPTOMYCES SP D788 .3. NEW ANTHRACYCLINE METABOLITES PRODUCED BY BLOCKED MUTANT-4L-660 AND MUTANT-YDK-18 [J].

YOSHIMOTO, A ;

JOHDO, O ;

NISHIDA, H ;

OKAMOTO, R ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1993, 46 (11) :1758-1761

[10] DAUNOMYCIN BIOSYNTHESIS BY MICROBIAL CONVERSION OF PRECURSOR METABOLITES USING BIOSYNTHETICALLY BLOCKED MUTANTS [J].

YOSHIMOTO, A ;

NAKAMURA, T ;

KUBO, K ;

JOHDO, O ;

TONE, H .

JOURNAL OF FERMENTATION AND BIOENGINEERING, 1995, 79 (03) :229-235