Ventral CA1 neurons store social memory

被引：461

作者：

Okuyama, Teruhiro ^{[1
,2
]}

Kitamura, Takashi ^{[1
,2
]}

Roy, Dheeraj S. ^{[1
,2
]}

Itohara, Shigeyoshi ^{[3
]}

Tonegawa, Susumu ^{[1
,2
,3
,4
]}

机构：

[1] MIT, Dept Biol, Picower Inst Learning & Memory, RIKEN MIT Ctr Neural Circuit Genet, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA

[3] RIKEN, Brain Sci Inst, Saitama 3510198, Japan

[4] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

SCIENCE | 2016年 / 353卷 / 6307期

基金：

日本学术振兴会;

关键词：

RECOGNITION MEMORY; CYTOTOXIC LESIONS; RAT HIPPOCAMPUS; ENGRAM CELLS; MICE; ORGANIZATION; REGION; BRAIN;

D O I：

10.1126/science.aaf7003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory.

引用

页码：1536 / 1541

页数：7

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