Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes

被引：7
作者：
Yu, Kuai [1 ,2 ]
Feng, Xiangqing [1 ,3 ]
Du, Haifeng [1 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China
[2] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 18期
基金：
中国国家自然科学基金;
关键词：
FRUSTRATED LEWIS PAIRS; HIGHLY ENANTIOSELECTIVE HYDROGENATION; METAL-FREE HYDROGENATIONS; KETOXIME ETHERS; REDUCTION; CHEMISTRY; IMINES; FLP;
D O I：
10.1039/d2ob00602b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective metal-free hydrogenation of TIPS-protected oximes has been successfully realized for the first time by using chiral borane catalysts derived from chiral dienes and Piers' borane. A variety of hydroxylamine derivatives were afforded in 84-99% yields with 33-68% ees.
引用
收藏
页码：3708 / 3711
页数：4
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