Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases

被引：42
作者：
Zhao, Yan [1 ,2 ]
Liu, You-Shuo [1 ,2 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Geriatr, Changsha, Peoples R China
[2] Cent South Univ, Inst Aging & Age Related Dis Res, Changsha, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
基金：
中国国家自然科学基金;
关键词：
FOXO3; aging; vascular aging; vascular homeostasis; cardiovascular disease; SMOOTH-MUSCLE-CELLS; MICROVASCULAR ENDOTHELIAL-CELLS; DEVELOPING RAT-BRAIN; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; UP-REGULATION; NITRIC-OXIDE; DNA-DAMAGE; LIFE-SPAN; AUTOPHAGY CONTRIBUTES;
D O I：
10.3389/fcvm.2021.778674
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Forkhead box O3 (FOXO3) has been proposed as a homeostasis regulator, capable of integrating multiple upstream signaling pathways that are sensitive to environmental changes and counteracting their adverse effects due to external changes, such as oxidative stress, metabolic stress and growth factor deprivation. FOXO3 polymorphisms are associated with extreme human longevity. Intriguingly, longevity-associated single nucleotide polymorphisms (SNPs) in human FOXO3 correlate with lower-than-average morbidity from cardiovascular diseases in long-lived people. Emerging evidence indicates that FOXO3 plays a critical role in vascular aging. FOXO3 inactivation is implicated in several aging-related vascular diseases. In experimental studies, FOXO3-engineered human ESC-derived vascular cells improve vascular homeostasis and delay vascular aging. The purpose of this review is to explore how FOXO3 regulates vascular aging and its crucial role in aging-related vascular diseases.
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页数：13
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