Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants

被引：357

作者：

Holst, Birgit ^{[1
]}

Williamson, Gary ^{[2
]}

机构：

[1] Nestec Ltd, Nestle Res Ctr, BioAnalyt Sci Dept, CH-1000 Lausanne 26, Switzerland

[2] Univ Leeds, Procter Dept Food Sci, Chair Funct Food, Leeds LS2 9JT, W Yorkshire, England

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2008年 / 19卷 / 02期

关键词：

D O I：

10.1016/j.copbio.2008.03.003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of any dietary compound is influenced by the active bioavailable dose rather than the dose ingested. Depending on the individual predisposition, including genetics and medication, a bioavailable dose may cause different magnitudes of effects in different people. Age might affect the predisposition and thus the requirements for nutrients including phytonutrients (e.g. phytochemicals such as flavonoids, phenolic acids and glucosinolates). These are not essential for growth and development but to maintain body functions and health throughout the adult and later phases of life; they are 'lifespan essentials'. Major mechanisms involved in chronic, age-related diseases include the oxidant/antioxidant balance, but the latest research indicates indirect effects of dietary bioactives in vivo and adaptive responses in addition to direct radical scavenging.

引用

页码：73 / 82

页数：10

共 44 条

[1] Oxidative stress: A dead end or a laboratory hypothesis? [J].

Azzi, Angelo .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 362 (02) :230-232

[2] Molecular mechanism of α-tocopherol action [J].

Azzi, Angelo .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 43 (01) :16-21

[3] Dietary ALEs are a risk to human health - NOT! [J].

Baynes, John W. .

MOLECULAR NUTRITION & FOOD RESEARCH, 2007, 51 (09) :1102-1106

[4] Biomarkers in pediatric environmental health: A cross-cutting issue [J].

Bearer, CF .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 :813-816

[5] Selenium and vitamin E status: Impact on viral pathogenicity [J].

Beck, Melinda A. .

JOURNAL OF NUTRITION, 2007, 137 (05) :1338-1340

[6] Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis [J].

Bjelakovic, G ;

Nikolova, D ;

Simonetti, RG ;

Gluud, C .

LANCET, 2004, 364 (9441) :1219-1228

[7] Induction of drug metabolizing enzymes by vitamin E [J].

Brigelius-Flohé, R .

JOURNAL OF PLANT PHYSIOLOGY, 2005, 162 (07) :797-802

[8] Part of the Series:: From dietary antioxidants to regulators in cellular signaling and gene regulation -: Sulforaphane and selenium, partners in adaptive response and prevention of cancer [J].

Brigelius-Flohe, Regina ;

Banning, Antje .

FREE RADICAL RESEARCH, 2006, 40 (08) :775-787

[9] Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework [J].

Calabrese, Edward J. ;

Bachmann, Kenneth A. ;

Bailer, A. John ;

Bolger, P. Michael ;

Borak, Jonathan ;

Cai, Lu ;

Cedergreen, Nina ;

Cherian, M. George ;

Chiueh, Chuang C. ;

Clarkson, Thomas W. ;

Cook, Ralph R. ;

Diamond, David M. ;

Doolittle, David J. ;

Dorato, Michael A. ;

Duke, Stephen O. ;

Feinendegen, Ludwig ;

Gardner, Donald E. ;

Hart, Ronald W. ;

Hastings, Kenneth L. ;

Hayes, A. Wallace ;

Hoffmann, George R. ;

Ives, John A. ;

Jaworowski, Zbigniew ;

Johnson, Thomas E. ;

Jonas, Wayne B. ;

Kaminski, Norbert E. ;

Keller, John G. ;

Klaunig, James E. ;

Knudsen, Thomas B. ;

Kozumbo, Walter J. ;

Lettleri, Teresa ;

Liu, Shu-Zheng ;

Maisseu, Andre ;

Maynard, Kenneth I. ;

Masoro, Edward J. ;

McClellan, Roger O. ;

Mehendale, Harlhara M. ;

Mothersill, Carmel ;

Newlin, David B. ;

Nigg, Herbert N. ;

Oehme, Frederick W. ;

Phalen, Robert F. ;

Philbert, Martin A. ;

Rattan, Suresh I. S. ;

Riviere, Jim E. ;

Rodricks, Joseph ;

Sapolsky, Robert M. ;

Scott, Bobby R. ;

Seymour, Colin ;

Sinclair, David A. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 222 (01) :122-128

[10] Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver [J].

Cavin, C. ;

Marin-Kuan, M. ;

Langouet, S. ;

Bezencon, C. ;

Guignard, G. ;

Verguet, C. ;

Piguet, D. ;

Holzhaeuser, D. ;

Cornaz, R. ;

Schilter, B. .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (04) :1239-1248

← 1 2 3 4 5 →