International consensus on the use of tau PET imaging agent 18F-flortaucipir in Alzheimer's disease

被引：44

作者：

Tian, Mei ^{[1
,2
,3
,4
]}

Civelek, A. Cahid ^{[5
]}

Carrio, Ignasi ^{[6
]}

Watanabe, Yasuyoshi ^{[7
]}

Kang, Keon Wook ^{[8
]}

Murakami, Koji ^{[9
]}

Garibotto, Valentina ^{[10
,11
]}

Prior, John O. ^{[12
]}

Barthel, Henryk ^{[13
]}

Zhou, Rui ^{[2
,3
]}

Hou, Haifeng ^{[2
,3
]}

Dou, Xiaofeng ^{[2
,3
]}

Jin, Chentao ^{[2
,3
]}

Zuo, Chuantao ^{[1
,14
,15
]}

Zhang, Hong ^{[2
,3
,16
,17
,18
]}

机构：

[1] Fudan Univ, Huashan Hosp, PET Ctr, Shanghai 200235, Peoples R China

[2] Zhejiang Univ, Dept Nucl Med, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, PET Ctr, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China

[4] Fudan Univ, Human Phenome Inst, Shanghai 201203, Peoples R China

[5] Johns Hopkins Med, Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

[6] Autonomous Univ Barcelona, Dept Nucl Med, Hosp St Pau, Barcelona 08025, Spain

[7] RIKEN, Lab Pathophysiol & Hlth Sci, Ctr Biosyst Dynam Res, Kobe, Hyogo 6500047, Japan

[8] Seoul Natl Univ, Dept Nucl Med, Coll Med, Seoul 03080, South Korea

[9] Juntendo Univ Hosp, Dept Radiol, Tokyo 1138431, Japan

[10] Univ Geneva, Univ Hosp Geneva, Diagnost Dept, Geneva, Switzerland

[11] Univ Geneva, NIMTlab, Geneva, Switzerland

[12] Lausanne Univ Hosp, Dept Nucl Med & Mol Imaging, Lausanne, Switzerland

[13] Univ Leipzig, Dept Nucl Med, Med Ctr, Leipzig, Germany

[14] Fudan Univ, Huashan Hosp, Natl Ctr Neurol Disorders, Shanghai 200040, Peoples R China

[15] Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai 200040, Peoples R China

[16] Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 310009, Peoples R China

[17] Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Hangzhou 310007, Peoples R China

[18] Zhejiang Univ, Key Lab Biomed Engn, Minist Educ, Hangzhou 310007, Peoples R China

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2022年 / 49卷 / 03期

基金：

中国国家自然科学基金; 瑞士国家科学基金会; 新加坡国家研究基金会;

关键词：

F-18-flortaucipir; Alzheimer's disease (AD); Positron emission tomography (PET); Brain imaging; NEUROFIBRILLARY TANGLES; DEMENTIA; DIAGNOSIS; PATHOLOGY;

D O I：

10.1007/s00259-021-05673-w

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose Positron emission tomography (PET) with the first and only tau targeting radiotracer of F-18-flortaucipir approved by FDA has been increasingly used in depicting tau pathology deposition and distribution in patients with cognitive impairment. The goal of this international consensus is to help nuclear medicine practitioners procedurally perform F-18-flortaucipir PET imaging. Method A multidisciplinary task group formed by experts from various countries discussed and approved the consensus for F-18-flortaucipir PET imaging in Alzheimer's disease (AD), focusing on clinical scenarios, patient preparation, and administered activities, as well as image acquisition, processing, interpretation, and reporting. Conclusion This international consensus and practice guideline will help to promote the standardized use of F-18-flortaucipir PET in patients with AD. It will become an international standard for this purpose in clinical practice.

引用

页码：895 / 904

页数：10

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