Effect of Ibandronate Therapy on Serum Chemerin, Vaspin, Omentin-1 and Osteoprotegerin (OPG) in Postmenopausal Osteoporotic Females

被引:9
作者
Tariq, Saba [1 ,2 ]
Tariq, Sundus [3 ,4 ]
Abualhamael, Shahad Abduljalil [5 ]
Shahzad, Muhammad [2 ]
机构
[1] Univ Faisalabad, Univ Med & Dent Coll, Dept Pharmacol & Therapeut, Faisalabad, Pakistan
[2] Univ Hlth Sci, Dept Pharmacol, Lahore, Pakistan
[3] Univ Faisalabad, Univ Med & Dent Coll, Dept Physiol & Cell Biol, Faisalabad, Pakistan
[4] Univ Hlth Sci, Dept Physiol, Lahore, Pakistan
[5] King Abdulaziz Univ, Dept Internal Med, Jeddah, Saudi Arabia
关键词
ibandronate; chemerin; vaspin; omentin-1; OPG; osteoporosis; BONE-MINERAL DENSITY; BISPHOSPHONATE TREATMENT; GENE-EXPRESSION; RANKL; ADIPONECTIN; WOMEN; VISFATIN; ACID; BMD;
D O I
10.3389/fphar.2022.822671
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Osteoporosis is a condition in which bone mineral density is reduced due to altered bone microstructure, which results in increased skeletal fragility and incidence of various types of fractures. Adipokines such as chemerin, vaspin, omentin-1 and osteoprotegerin are involved in bone remodeling. The current study was designed to determine the changes in circulating chemerin, vaspin, omentin-1, and osteoprotegerin levels after treatment with oral ibandronate 150 mg in postmenopausal osteoporotic females. The present study enrolled 107 postmenopausal osteoporotic females from a tertiary care hospital in Faisalabad, Pakistan, based on stringent inclusion and exclusion criteria. Sixty-six healthy postmenopausal, non-osteoporotic females with no systemic illness were chosen from the general population. The assessment of bone mineral density (BMD) was done using a DEXA scan. Serum levels of chemerin, vaspin, omentin-1 and osteoprotegerin were estimated using commercially available enzyme-linked immunosorbent assay kits. The collected data were analyzed with the Statistical Package for Social Sciences (SPSS) version 24. Following 6 months of ibandronate treatment, there was a significant decrease of 24.24% (p < .033) in serum chemerin levels, as well as a significant increase in serum vaspin levels 343.32% (p < .001) and osteoprotegerin levels 19.57% (p < .001), with no significant change in omentin-1 levels. Thus, an increase in serum chemerin levels and a decrease in serum vaspin and osteoprotegerin levels could be implicated in osteoporosis.
引用
收藏
页数:11
相关论文
共 43 条
[1]   Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density [J].
Azizieh, Fawaz Y. ;
Shehab, Diaa ;
Al Jarallah, Khaled ;
Gupta, Renu ;
Raghupathy, Raj .
BIOMARKER INSIGHTS, 2019, 14
[2]   Changes in RANKL/OPG/RANK gene expression in peripheral mononuclear cells following treatment with estrogen or raloxifene [J].
Bashir, A ;
Mak, Y ;
Sankaralingam, S ;
Cheung, J ;
Mc Gowan, NWA ;
Grigoriadis, AE ;
Fogelman, I ;
Hampson, G .
STEROIDS, 2005, 70 (13) :847-855
[3]   Evaluation of the Relation Between Omentin-1 and Vitamin D in Postmenopausal Women With or Without Osteoporosis [J].
Dikker, Okan ;
Bekpinar, Seldag ;
Ozdemirler, Gul ;
Uysal, Mujdat ;
Vardar, Muberra ;
Atar, Sevgi ;
Usta, Murat ;
Huner, Berrin .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2018, 126 (05) :316-320
[4]  
Engin-Ustun Yaprak, 2016, J Menopausal Med, V22, P76, DOI 10.6118/jmm.2016.22.2.76
[5]  
Falaschi P., 2017, ORTHOGERIATRICS, P31, DOI [10.1007/978-3-319-43249-6_3, DOI 10.1007/978-3-319-43249-6_3]
[6]   New roles of the multidimensional adipokine: Chemerin [J].
Fatima, Syeda Sadia ;
Rehman, Rehana ;
Baig, Mukhtiar ;
Khan, Taseer Ahmed .
PEPTIDES, 2014, 62 :15-20
[7]   Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature [J].
Gorecki, Patricia ;
Stockmann, Philipp ;
Distler, Joerg H. W. ;
Wuest, Wolfgang ;
Schmidt, Daniela ;
Neukam, Friedrich Wilhelm ;
Nkenke, Emeka ;
Wehrhan, Falk .
JOURNAL OF MEDICAL HYPOTHESES AND IDEAS, 2015, 9 (02) :72-78
[8]   Monthly oral ibandronate 100 mg is as effective as monthly intravenous ibandronate 1 mg in patients with various pathologies in the MOVEST study [J].
Hagino, Hiroshi ;
Ito, Masako ;
Hashimoto, Junko ;
Yamamoto, Masao ;
Endo, Koichi ;
Katsumata, Kyoko ;
Asao, Yoshihiro ;
Matsumoto, Rumiko ;
Nakano, Tetsuo ;
Mizunuma, Hideki ;
Nakamura, Toshitaka .
JOURNAL OF BONE AND MINERAL METABOLISM, 2018, 36 (03) :336-343
[9]   Associations Between Plasma Chemerin Concentrations and Bone Quality in Adults From the General Population [J].
Kadric, Lejla ;
Zylla, Stephanie ;
Nauck, Matthias ;
Voelzke, Henry ;
Friedrich, Nele ;
Hannemann, Anke .
ENDOCRINOLOGY, 2018, 159 (06) :2378-2385
[10]   Vaspin Attenuates RANKL-Induced Osteoclast Formation in RAW264.7 Cells [J].
Kamio, Noriaki ;
Kawato, Takayuki ;
Tanabe, Natsuko ;
Kitami, Satoshi ;
Morita, Toyoko ;
Ochiai, Kuniyasu ;
Maeno, Masao .
CONNECTIVE TISSUE RESEARCH, 2013, 54 (02) :147-152