Yeast life-span extension by calorie restriction is independent of NAD fluctuation

被引：126

作者：

Anderson, RM

Latorre-Esteves, M

Neves, AR

Lavu, S

Medvedik, O

Taylor, C

Howitz, KT

Santos, H

Sinclair, DA

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Univ Nova Lisboa, Inst Tecnol Quim & Biol, P-2780156 Oeiras, Portugal

[3] Biomol Res Labs Inc, Plymouth Meeting, PA 19462 USA

来源：

SCIENCE | 2003年 / 302卷 / 5653期

关键词：

D O I：

10.1126/science.1088697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD(+)-dependent deacetylase. We report that CR reduces nuclear NAD(+) levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD(+): NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.

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页码：2124 / 2126

页数：3

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