Anti-PD-1 therapy using cemiplimab for advanced cutaneous squamous cell carcinoma in HIV patient: A case report

被引：2

作者：

Alloghbi, Abdurahman ^{[1
]}

Ninia, James ^{[2
]}

Alshare, Bayan ^{[1
]}

Hotaling, Jeffrey ^{[3
]}

Raza, Syed ^{[3
]}

Sukari, Ammar ^{[1
]}

机构：

[1] Wayne State Univ, Dept Oncol, Karmanos Canc Inst, Detroit, MI 48202 USA

[2] Wayne State Univ, Sch Med, Detroit, MI USA

[3] Karmanos Canc Inst, Dept Surg Oncol, Detroit, MI USA

来源：

CLINICAL CASE REPORTS | 2021年 / 9卷 / 12期

关键词：

advanced cutaneous squamous cell carcinoma; cemiplimab; immunotherapy; skin cancer; squamous cell carcinoma; BLOCKADE; PEMBROLIZUMAB;

D O I：

10.1002/ccr3.5228

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This is a case of a 60-year-old man living with HIV who presented with advanced cutaneous squamous cell carcinoma. After workup, medical and surgical treatment, and disease recurrence, he achieved a complete response with no unexpected toxicities after immunotherapy with cemiplimab.

引用

页数：4

共 19 条

[1] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[2] Changes in Cancer Mortality among HIV-Infected Patients: The Mortalite 2005 Survey [J].

Bonnet, Fabrice ;

Burty, Christine ;

Lewden, Charlotte ;

Costagliola, Dominique ;

May, Thierry ;

Bouteloup, Vincent ;

Rosenthal, Eric ;

Jougla, Eric ;

Cacoub, Patrice ;

Salmon, Dominique ;

Chene, Genevieve ;

Morlat, Philippe .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (05) :633-639

[3] Mechanisms regulating PD-L1 expression on tumor and immune cells [J].

Chen, Shuming ;

Crabill, George A. ;

Pritchard, Theresa S. ;

McMiller, Tracee L. ;

Wei, Ping ;

Pardoll, Drew M. ;

Pan, Fan ;

Topalian, Suzanne L. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01)

[4] Drastic decrease of the HIV reservoir in a patient treated with nivolumab for lung cancer [J].

Guihot, A. ;

Marcelin, A-G. ;

Massiani, M-A. ;

Samri, A. ;

Soulie, C. ;

Autran, B. ;

Spano, J-P. .

ANNALS OF ONCOLOGY, 2018, 29 (02) :517-518

[5] Immune Checkpoint Inhibitors [J].

Haanen, John B. A. G. ;

Robert, Caroline .

IMMUNO-ONCOLOGY, 2015, 42 :55-66

[6] Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial [J].

Herbst, Roy S. ;

Baas, Paul ;

Kim, Dong-Wan ;

Felip, Enriqueta ;

Perez-Gracia, Jose L. ;

Han, Ji-Youn ;

Molina, Julian ;

Kim, Joo-Hang ;

Arvis, Catherine Dubos ;

Ahn, Myung-Ju ;

Majem, Margarita ;

Fidler, Mary J. ;

de Castro, Gilberto, Jr. ;

Garrido, Marcelo ;

Lubiniecki, Gregory M. ;

Shentu, Yue ;

Im, Ellie ;

Dolled-Filhart, Marisa ;

Garon, Edward B. .

LANCET, 2016, 387 (10027) :1540-1550

[7] Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC [J].

Huang Jian ;

Shen Fangrong ;

Huang Haitao ;

Ling Chunhua ;

Zhang Guangbo .

ONCOTARGET, 2017, 8 (08) :13116-13125

[8] PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma [J].

Migden, M. R. ;

Rischin, D. ;

Schmults, C. D. ;

Guminski, A. ;

Hauschild, A. ;

Lewis, K. D. ;

Chung, C. H. ;

Hernandez-Aya, L. ;

Lim, A. M. ;

Chang, A. L. S. ;

Rabinowits, G. ;

Thai, A. A. ;

Dunn, L. A. ;

Hughes, B. G. M. ;

Khushalani, N. I. ;

Modi, B. ;

Schadendorf, D. ;

Gao, B. ;

Seebach, F. ;

Li, S. ;

Li, J. ;

Mathias, M. ;

Booth, J. ;

Mohan, K. ;

Stankevich, E. ;

Babiker, H. M. ;

Brana, I. ;

Gil-Martin, M. ;

Homsi, J. ;

Johnson, M. L. ;

Moreno, V. ;

Niu, J. ;

Owonikoko, T. K. ;

Papadopoulos, K. P. ;

Yancopoulos, G. D. ;

Lowy, I. ;

Fury, M. G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (04) :341-351

[9] Causes of death among HIV-infected patients in France in 2010 (national survey): trends since 2000 [J].

Morlat, Philippe ;

Roussillon, Caroline ;

Henard, Sandrine ;

Salmon, Dominique ;

Bonnet, Fabrice ;

Cacoub, Patrice ;

Georget, Aurore ;

Aouba, Albertine ;

Rosenthal, Eric ;

May, Thierry ;

Chauveau, Marie ;

Diallo, Bilghissa ;

Costagliola, Dominique ;

Chene, Genevieve .

AIDS, 2014, 28 (08) :1181-1191

[10] VIRUS PERSISTENCE IN ACUTELY INFECTED IMMUNOCOMPETENT MICE BY EXHAUSTION OF ANTIVIRAL CYTOTOXIC EFFECTOR T-CELLS [J].

MOSKOPHIDIS, D ;

LECHNER, F ;

PIRCHER, H ;

ZINKERNAGEL, RM .

NATURE, 1993, 362 (6422) :758-761

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