Chemical agents protective against rotenone-induced neurotoxicity

被引：5
作者：
Najafi, Nahid [1 ,2 ]
Rahbardar, Mahboobeh Ghasemzadeh [3 ]
Hosseinzadeh, Hossein [2 ,3 ]
Hayes, A. Wallace [4 ]
Karimi, Gholamreza [2 ,3 ]
机构：
[1] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran
[3] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran
[4] Univ S Florida, Coll Publ Hlth, Dept Toxicol, Tampa, FL 33620 USA
来源：
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2022年 / 104卷 / 01期
关键词：
Neuroprotective; mitochondrial complex I; oxidative stress; apoptosis; autophagy; INDUCED OXIDATIVE STRESS; INDUCED TOXICITY; DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; SH-SY5Y CELLS; INDUCED DEGENERATION; AUTOPHAGIC FLUX; BRAIN-INJURY; IN-VIVO; RIFAMPICIN;
D O I：
10.1080/02772248.2022.2030341
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Rotenone is a broadly used organic pesticide with neurotoxicity as a serious side effect for non-target organisms. The inhibition of mitochondrial complex I is the principal mechanism of rotenone toxicity that leads to oxidative stress, apoptosis, and decreased autophagy. Several chemical compounds have been demonstrated to exhibit antioxidant, antiapoptotic, and autophagy enhancement in both in vitro and in vivo studies. Some chemical agents can ameliorate rotenone-induced neurotoxicity through their antioxidant, anti-inflammatory, and anti-apoptotic properties. They also inhibit the accumulation of alpha-synuclein, control dopamine release, affect ion channels, and induce autophagy. Clinical trials are essential to reinforce the effectiveness of any chemical in managing patients with rotenone neurotoxicity.
引用
收藏
页码：149 / 175
页数：27
相关论文
共 50 条
[31]   RAPAMYCIN PROTECTS AGAINST ROTENONE-INDUCED APOPTOSIS THROUGH AUTOPHAGY INDUCTION [J].
Pan, T. ;
Rawal, P. ;
Wu, Y. ;
Xie, W. ;
Jankovic, J. ;
Le, W. .
NEUROSCIENCE, 2009, 164 (02) :541-551
[32]   Protective effect of (-)-α-bisabolol on rotenone-induced toxicity in Drosophila melanogaster [J].
Leite, Gerlania de Oliveira ;
Ecker, Assis ;
Seeger, Rodrigo Lopes ;
Krum, Barbara Nunes ;
Lugokenski, Thiago Henrique ;
Fachinetto, Roselei ;
Sudati, Jessie Haigert ;
Barbosa, Nilda Vargas ;
Wagner, Caroline .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2018, 96 (04) :359-365
[33]   The potential role of Portulaca oleracea as a neuroprotective agent in rotenone-induced neurotoxicity and apoptosis in the brain of rats [J].
Moneim, Ahmed E. Abdel ;
Dkhil, Mohamed A. ;
Al-Quraishy, Saleh .
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2013, 105 (03) :203-212
[34]   Protective effects of curcumin against rotenone-induced rat model of Parkinson's disease: in vivo electrophysiological and behavioral study [J].
Darbinyan, L. V. ;
Hambardzumyan, L. E. ;
Simonyan, K. V. ;
Chavushyan, V. A. ;
Manukyan, L. P. ;
Badalyan, S. A. ;
Khalaji, N. ;
Sarkisian, V. H. .
METABOLIC BRAIN DISEASE, 2017, 32 (06) :1791-1803
[35]   Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis [J].
Khalil, Wagdy K. B. ;
Assaf, Naglaa ;
ElShebiney, Shaimaa A. ;
Salem, Neveen A. .
NEUROCHEMISTRY INTERNATIONAL, 2015, 80 :79-86
[36]   Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells [J].
Tan, Zhen ;
Xu, Huamin ;
Shen, Xiaoli ;
Jiang, Hong .
PEPTIDES, 2015, 69 :109-114
[37]   Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease [J].
De Miranda, Briana R. ;
Rocha, Emily M. ;
Bai, Qing ;
El Ayadi, Amina ;
Hinkle, David ;
Burton, Edward A. ;
Greenamyre, J. Timothy .
NEUROBIOLOGY OF DISEASE, 2018, 115 :101-114
[38]   Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity [J].
Peng, Kaige ;
Tao, Yuan ;
Zhang, Jun ;
Wang, Jian ;
Ye, Feng ;
Dan, Guorong ;
Zhao, Yuanpeng ;
Cai, Ying ;
Zhao, Jiqing ;
Wu, Qiang ;
Zou, Zhongmin ;
Cao, Jia ;
Sai, Yan .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
[39]   Icariin protects rotenone-induced neurotoxicity through induction of SIRT3 [J].
Zeng, Ru ;
Wang, Xueting ;
Zhou, Qian ;
Fu, Xiaolong ;
Wu, Qin ;
Lu, Yuanfu ;
Shi, Jingshan ;
Klaunig, James E. ;
Zhou, Shaoyu .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 379
[40]   Resveratrol Confers Protection against Rotenone-Induced Neurotoxicity by Modulating Myeloperoxidase Levels in Glial Cells [J].
Chang, Chi Young ;
Choi, Dong-Kug ;
Lee, Dae Kee ;
Hong, Young Jun ;
Park, Eun Jung .
PLOS ONE, 2013, 8 (04)
12345