A genome screen for multiple sclerosis in Italian families

被引：60

作者：

Broadley, S

Sawcer, S

D'Alfonso, S

Hensiek, A

Coraddu, F

Gray, J

Roxburgh, R

Clayton, D

Buttinelli, C

Quattrone, A

Trojano, M

Massacesi, L

Compston, A

机构：

[1] Univ Florence, Dip Sci Neurol & Psichiat, I-50134 Florence, Italy

[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[3] Univ Piermonte Orientale A Avogadro, Dept Med Sci, Chair Human Genet, Novara, Italy

[4] Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2SR, England

[5] Univ La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

[6] Univ Catanzaro, Dept Med Sci, Catanzaro, Italy

[7] CNR, Inst Expt Med & Biotechnol, I-00185 Rome, Italy

[8] Univ Bari, Dept Neurol & Psychiat Sci, I-70121 Bari, Italy

[9] Univ Florence, Dept Neurol & Psychait Sci, I-50121 Florence, Italy

来源：

GENES AND IMMUNITY | 2001年 / 2卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

multiple sclerosis; linkage; genome screen; genetic susceptibility;

D O I：

10.1038/sj.gene.6363758

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

引用

页码：205 / 210

页数：6

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