Induction of IFN-g production by IL-12 and IL-18: a link between innate and acquired immune responses

被引：0
|
作者：
Darwich, L. [1 ,2 ]
Jimenez, E. [2 ]
Gomas, G. [2 ]
Pena, R. [2 ]
Blanco, J. [2 ]
Este, J. A. [2 ]
Clotel, B. [2 ]
Ruiz, L. [2 ]
Borras, F. E.
Bolill, M. [2 ,3 ,4 ]
机构：
[1] Univ Autonoma Barcelona, Barcelona, Spain
[2] Irsicaixa Fdn, Barcelona, Spain
[3] Fundacio Germans Trias & Pujol, Badalona, Spain
[4] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
来源：
2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI) | 2009年
关键词：
(IL)-12 PLUS IL-18; INTERFERON-GAMMA; MACROPHAGES;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have described a possible role for IL-12 and IL-18 in the initiation, and resolution of innate immune response to pathogens, as they can induce the aggregation and maturation of monocytes, the induction of inflammatory chemokines (CXCL-8, CCL2, CXCL9, CXCL10). They also induce the production of IFN gamma in the absence of NK or T-cells, suggesting a role for INF gamma in innate immunity.
引用
收藏
页码：561 / +
页数：2
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