Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1

被引：2

作者：

van Montfort, T. ^{[1
]}

Speijer, D. ^{[2
]}

Berkhout, B. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, Lab Expt Virol, Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, Amsterdam, Netherlands

来源：

VIRULENCE | 2017年 / 8卷 / 08期

关键词：

dendritic cells; HIV-1; latency; latency reversing agent; REPLICATION; ACTIVATION; PERSISTENCE; PROVIRUSES;

D O I：

10.1080/21505594.2017.1371898

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：1494 / 1497

页数：4

共 29 条

[1] Defective proviruses rapidly accumulate during acute HIV-1 infection [J].

Bruner, Katherine M. ;

Murray, Alexandra J. ;

Pollack, Ross A. ;

Soliman, Mary G. ;

Laskey, Sarah B. ;

Capoferri, Adam A. ;

Lai, Jun ;

Strain, Matthew C. ;

Lada, Steven M. ;

Hoh, Rebecca ;

Ho, Ya-Chi ;

Richman, Douglas D. ;

Deeks, Steven G. ;

Siliciano, Janet D. ;

Siliciano, Robert F. .

NATURE MEDICINE, 2016, 22 (09) :1043-+

[2] New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo [J].

Bullen, C. Korin ;

Laird, Gregory M. ;

Durand, Christine M. ;

Siliciano, Janet D. ;

Siliciano, Robert F. .

NATURE MEDICINE, 2014, 20 (04) :425-+

[3] HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation [J].

Chomont, Nicolas ;

El-Far, Mohamed ;

Ancuta, Petronela ;

Trautmann, Lydie ;

Procopio, Francesco A. ;

Yassine-Diab, Bader ;

Boucher, Genevieve ;

Boulassel, Mohamed-Rachid ;

Ghattas, Georges ;

Brenchley, Jason M. ;

Schacker, Timothy W. ;

Hill, Brenna J. ;

Douek, Daniel C. ;

Routy, Jean-Pierre ;

Haddad, Elias K. ;

Sekaly, Rafick-Pierre .

NATURE MEDICINE, 2009, 15 (08) :893-U92

[4] AIDS - Re-emergence of HIV after stopping therapy [J].

Chun, TW ;

Davey, RT ;

Engel, D ;

Lane, HC ;

Fauci, AS .

NATURE, 1999, 401 (6756) :874-875

[5] Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines [J].

Chun, TW ;

Engel, D ;

Mizell, SB ;

Ehler, LA ;

Fauci, AS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (01) :83-91

[6]

COLEMAN CM, 2009, RETR INT, V6, DOI DOI 10.1186/1742-4690-6-51

[7] An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression [J].

Darcis, Gilles ;

Kula, Anna ;

Bouchat, Sophie ;

Fujinaga, Koh ;

Corazza, Francis ;

Ait-Ammar, Amina ;

Delacourt, Nadege ;

Melard, Adeline ;

Kabeya, Kabamba ;

Vanhulle, Caroline ;

Van Driessche, Benoit ;

Gatot, Jean-Stephane ;

Cherrier, Thomas ;

Pianowski, Luiz F. ;

Gama, Lucio ;

Schwartz, Christian ;

Vila, Jorge ;

Burny, Arsene ;

Clumeck, Nathan ;

Moutschen, Michel ;

De Wit, Stephane ;

Peterlin, B. Matija ;

Rouzioux, Christine ;

Rohr, Olivier ;

Van Lint, Carine .

PLOS PATHOGENS, 2015, 11 (07)

[8] Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents [J].

Delagreverie, Heloise M. ;

Delaugerre, Constance ;

Lewin, Sharon R. ;

Deeks, Steven G. ;

Li, Jonathan Z. .

OPEN FORUM INFECTIOUS DISEASES, 2016, 3 (04)

[9] Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy [J].

Finzi, D ;

Blankson, J ;

Siliciano, JD ;

Margolick, JB ;

Chadwick, K ;

Pierson, T ;

Smith, K ;

Lisziewicz, J ;

Lori, F ;

Flexner, C ;

Quinn, TC ;

Chaisson, RE ;

Rosenberg, E ;

Walker, B ;

Gange, S ;

Gallant, J ;

Siliciano, RF .

NATURE MEDICINE, 1999, 5 (05) :512-517

[10] OPERating ON Chromatin, a Colorful Language where Context Matters [J].

Gardner, Kathryn E. ;

Allis, C. David ;

Strahl, Brian D. .

JOURNAL OF MOLECULAR BIOLOGY, 2011, 409 (01) :36-46

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