The telescopes aboard NASA's Compton Observatory have recorded gamma-ray line signals from several radioactive species: Co-57, Ti-44, Al-26, and possibly Co-56. Radioactivities in the universe provide a direct measure of current nucleosynthesis processes through the gamma-ray lines emitted in the radioactive decay. Different isotope lifetimes address complementary astrophysical questions ranging from integrated nucleosynthesis event frequencies in the Galaxy to nucleosynthesis yields of specific stars or supernova events. We discuss results from the on-going Compton mission, and address issues relevant to nuclear astrophysics.