Transcription Factor C/eBP Homologous Protein in Health and Diseases

被引：159

作者：

Yang, Yuan ^{[1
,2
]}

Liu, Lian ^{[3
]}

Naik, Ishan ^{[4
]}

Braunstein, Zachary ^{[5
]}

Zhong, Jixin ^{[4
]}

Ren, Boxu ^{[1
,2
]}

机构：

[1] Yangtze Univ, Ctr Mol Med, Med Sch, Jingzhou, Peoples R China

[2] Yangtze Univ, Dept Radiol, Med Sch, Jingzhou, Peoples R China

[3] Yangtze Univ, Dept Pharmacol, Med Sch, Jingzhou, Peoples R China

[4] Case Western Reserve Univ, Cardiovasc Res Inst, Cleveland, OH 44106 USA

[5] Wright State Univ, Boonshoft Sch Med, Dayton, OH 45435 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

基金：

中国国家自然科学基金;

关键词：

C/EBP homologous protein; apoptosis; endoplasmic reticulum stress; fibrosis; cancer; neurodegenerative disorders; diabetes; ENDOPLASMIC-RETICULUM-STRESS; PANCREATIC BETA-CELLS; INDUCED PULMONARY-FIBROSIS; COLON-CANCER CELLS; REGULATES OSTEOBLAST DIFFERENTIATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHOP FUSION PROTEIN; DEATH RECEPTOR 5; ER-STRESS; INDUCED APOPTOSIS;

D O I：

10.3389/fimmu.2017.01612

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

C/EBP homologous protein (CHOP), known also as DNA damage-inducible transcript 3 and as growth arrest and DNA damage-inducible protein 153 (GADD153), is induced in response to certain stressors. CHOP is universally acknowledged as a main conduit to endoplasmic reticulum stress-induced apoptosis. Ongoing research established the existence of CHOP-mediated apoptosis signaling networks, for which novel downstream targets are still being determined. However, there are studies that contradict this notion and assert that apoptosis is not the only mechanism by which CHOP plays in the development of pathologies. In this review, insights into the roles of CHOP in pathophysiology are summarized at the molecular and cellular levels. We further focus on the newest advances that implicate CHOP in human diseases including cancer, diabetes, neurodegenerative disorders, and notably, fibrosis.

引用

页数：18

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