New sesquiterpene lactones from Ambrosia cumanensis Kunth

被引：14

作者：

del Socorro Jimenez-Usuga, Nora ^{[1
]}

Malafronte, Nicola ^{[2
]}

Cotugno, Roberta ^{[2
]}

De Leo, Marinella ^{[3
]}

Osorio, Edison ^{[1
]}

De Tommasi, Nunziatina ^{[2
]}

机构：

[1] UdeA, Fac Ciencias Farmaceut & Alimentarias, Grp Invest Sustancias Bioact, Calle 70 52-21, Medellin, Colombia

[2] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo 2, I-84084 Salerno, Italy

[3] Univ Pisa, Dipartimento Farm, Via Bonanno 33, I-56126 Pisa, Italy

来源：

FITOTERAPIA | 2016年 / 113卷

关键词：

Ambrosia cumanensis; Asteraceae; Sesquiterpene lactones; Cytotoxic activity; MEDICINAL-PLANTS; HYMENOCLEA-SALSOLA; PSEUDOGUAIANOLIDES;

D O I：

10.1016/j.fitote.2016.07.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eleven sesquiterpene lactones, including three new natural products (1-3), were isolated from the n-butanolic extract of Ambrosia cumanensis Kunth. aerial parts. The structure of all isolated compounds was elucidated by ID- and 2D-NMR, and MS analyses. All compounds were tested for their antiproliferative activity on HeLa, Jurkat, and U937 cell lines. Compound 3, 2,3-dehydropsilostachyn C, showed cytotoxic activity with different potency in all cell lines. By means of flow cytometric studies, compound 3 was demonstrated to induce in Jurkat cells a G(2)/M cell cycle block, while in U937 elicited both cytostatic and cytotoxic responses. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：170 / 174

页数：5