Recent Progress in Oleanolic Acid: Structural Modification and Biological Activity

被引：12

作者：

Wang, Wang ^{[1
]}

Li, Yutong ^{[1
]}

Li, Yan ^{[1
]}

Sun, Dejuan ^{[1
]}

Li, Hua ^{[1
,2
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Oleanolic acid; Structural modification; Bioactivity; Drug discovery; Anticancer; Anti-inflammatory; BARDOXOLONE METHYL; PENTACYCLIC TRITERPENOIDS; BECKMANN REARRANGEMENT; BETULINIC ACID; HEART-FAILURE; CDDO-ME; DERIVATIVES; DESIGN; INHIBITORS; MECHANISM;

D O I：

10.2174/1568026621666211105101231

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Natural products have been proven as the main source of biologically active compounds, which are potentially useful for drug development. As one of the most studied pentacyclic triterpenes, oleanolic acid (OA) exhibits a broad range of biological activities and serves as a good scaffold for the development of novel derivatives that could be vital in drug discovery for various ailments. Till now, many of its derivatives with multiple bioactivities have been prepared through chemical modifi-cation. This review summarizes the recent reports of OA derivatives (2016-present) and their biologi -cal effects and action mechanisms in vitro and in vivo models, and discusses the design of novel and potent derivatives.

引用

页码：3 / 23

页数：21

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