Sickle cell disease and malaria morbidity: a tale with two tails

被引：61

作者：

Williams, Thomas N. ^{[1
,2
,3
,4
,5
]}

Obaro, Stephen K. ^{[6
,7
]}

机构：

[1] KEMRI Ctr Geog Med Res Coast, Kilifi, Kenya

[2] Univ Oxford, Dept Paediat, Oxford, England

[3] Univ Oxford, Nuffield Dept Med, Oxford, England

[4] INDEPTH Network Demog Surveillance Sites, Accra, Ghana

[5] EVIMaIR Network, Glasgow, Lanark, Scotland

[6] Michigan State Univ, Dept Pediat & Human Dev, Div Pediat Infect Dis, E Lansing, MI 48824 USA

[7] Natl Hosp, Abuja, Nigeria

来源：

TRENDS IN PARASITOLOGY | 2011年 / 27卷 / 07期

基金：

英国惠康基金;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; REPUBLIC-OF-BENIN; NATURAL-HISTORY; CHILDREN; ANEMIA; AFRICA; KENYA; MORTALITY; INFECTION; ALPHA(+)-THALASSEMIA;

D O I：

10.1016/j.pt.2011.02.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

More than 230 000 children are born in Africa with sickle cell disease (SCD) each year: approximately 85% of all affected births worldwide. Although malaria is commonly viewed as a major problem for African patients with this condition, questions still remain about its relative importance as a cause of ill heath and death. In the absence of definitive studies investigating the contribution of malaria to morbidity and mortality in African children with SCD, policy makers will continue to lack the evidence on which to base appropriate management guidelines.

引用

页码：315 / 320

页数：6

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