A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis

被引：32
作者：
Snider, MD [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
来源：
MOLECULAR CELL | 2003年 / 12卷 / 04期
关键词：
D O I：
10.1016/S1097-2765(03)00401-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When growth factors are removed from many mammalian cells, growth ceases and apoptosis is induced. The small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediating the regulated internalization and degradation of nutrient transporters. This process triggers nutrient starvation that helps to induce cell death.
引用
收藏
页码：796 / 797
页数：2
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