Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

被引:656
作者
Brinkman, K
ter Hofstede, HJM
Burger, DM
Smeitinkt, JAM
Koopmans, PP
机构
[1] Univ Nijmegen Hosp, Dept Gen Internal Med, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen Hosp, Dept Clin Pharm, NL-6500 HB Nijmegen, Netherlands
[3] Univ Nijmegen Hosp, Dept Paediat, NL-6500 HB Nijmegen, Netherlands
关键词
HIV infection; nucleoside analogues; non-nucleoside analogues; nucleotide analogues; drug reactions; human DNA polymerases; DNA polymerase gamma; mitochondrial toxicity;
D O I
10.1097/00002030-199814000-00004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:1735 / 1744
页数:10
相关论文
共 109 条
[1]  
Aber V, 1996, LANCET, V348, P283, DOI 10.1016/S0140-6736(96)05387-1
[2]   Zalcitabine - An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection [J].
Adkins, JC ;
Peters, DH ;
Faulds, D .
DRUGS, 1997, 53 (06) :1054-1080
[3]  
AGGARWAL A, 1996, MD MED J, V45, P929
[4]  
ALBERTS B, 1994, MOL BIOL CELL, P655
[5]   DEPLETION OF MUSCLE MITOCHONDRIAL-DNA IN AIDS PATIENTS WITH ZIDOVUDINE-INDUCED MYOPATHY [J].
ARNAUDO, E ;
DALAKAS, M ;
SHANSKE, S ;
MORAES, CT ;
DIMAURO, S ;
SCHON, EA .
LANCET, 1991, 337 (8740) :508-510
[6]   THE INVITRO AND INVIVO ANTI-RETROVIRUS ACTIVITY, AND INTRACELLULAR METABOLISM OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE AND 2',3'-DIDEOXYCYTIDINE ARE HIGHLY DEPENDENT ON THE CELL SPECIES [J].
BALZARINI, J ;
PAUWELS, R ;
BABA, M ;
HERDEWIJN, P ;
DECLERCQ, E ;
BRODER, S ;
JOHNS, DG .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) :897-903
[7]  
BARRIERE S, 1998, 12 WORLD AIDS C GEN
[8]   Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells [J].
Benbrik, E ;
Chariot, P ;
Bonavaud, S ;
AmmiSaid, M ;
Frisdal, E ;
Rey, C ;
Gherardi, R ;
BarlovatzMeimon, G .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 149 (01) :19-25
[9]   FULMINANT-HEPATITIS WITH SEVERE LACTATE ACIDOSIS IN HIV-INFECTED PATIENTS ON DIDANOSINE THERAPY [J].
BISSUEL, F ;
BRUNEEL, F ;
HABERSETZER, F ;
CHASSARD, D ;
COTTE, L ;
CHEVALLIER, M ;
BERNUAU, J ;
LUCET, JC ;
TREPO, C .
JOURNAL OF INTERNAL MEDICINE, 1994, 235 (04) :367-371
[10]  
BRINKMAN K, 1998, 12 WORLD AIDS C GEN